Abstract
Depression is associated with increased morbidity and mortality in patients with coronary heart disease (CHD). Increased platelet activation has been proposed as a potential mechanism by which depression may lead to adverse cardiovascular outcomes. In this cross-sectional study, we measured platelet activation in 104 patients with stable CHD, including 58 with a current episode of major depression and 46 without past or current major depression. Participants were instructed not to take aspirin for 7 days prior to the study appointment. Platelet activation was measured by plasma concentrations of platelet factor 4 (PF4) and beta-thromboglobulin (β-TG), and by 24-h urinary concentrations of 11-dehydro-thromboxane B2 (TBXB2). We observed no differences in the mean levels of PF4, B-TG or TBXB2 in patients with and without major depression. Results were unchanged after adjustment for age, smoking, use of aspirin, and use of any psychotropic medication. We found no evidence of an association between major depression and platelet activation as measured by plasma concentrations of PF4 and β-TG, or urinary TBXB2 in 104 outpatients with stable CHD. These findings do not support a role for platelet activation in the association between depression and cardiovascular disease among patients with stable CHD.
| Original language | English |
|---|---|
| Pages (from-to) | 200-204 |
| Number of pages | 5 |
| Journal | Psychiatry Research |
| Volume | 175 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 28 2010 |
| Externally published | Yes |
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Keywords
- Coronary heart disease
- Depression
- Mechanisms
- Platelet activation
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Depression and platelet activation in outpatients with stable coronary heart disease : Findings from the Heart and Soul Study. / Gehi, Anil; Musselman, Dominique; Otte, Christian; Bruce Royster, Erica; Ali, Sadia; Whooley, Mary A.
In: Psychiatry Research, Vol. 175, No. 3, 28.02.2010, p. 200-204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression and platelet activation in outpatients with stable coronary heart disease
T2 - Findings from the Heart and Soul Study
AU - Gehi, Anil
AU - Musselman, Dominique
AU - Otte, Christian
AU - Bruce Royster, Erica
AU - Ali, Sadia
AU - Whooley, Mary A.
PY - 2010/2/28
Y1 - 2010/2/28
N2 - Depression is associated with increased morbidity and mortality in patients with coronary heart disease (CHD). Increased platelet activation has been proposed as a potential mechanism by which depression may lead to adverse cardiovascular outcomes. In this cross-sectional study, we measured platelet activation in 104 patients with stable CHD, including 58 with a current episode of major depression and 46 without past or current major depression. Participants were instructed not to take aspirin for 7 days prior to the study appointment. Platelet activation was measured by plasma concentrations of platelet factor 4 (PF4) and beta-thromboglobulin (β-TG), and by 24-h urinary concentrations of 11-dehydro-thromboxane B2 (TBXB2). We observed no differences in the mean levels of PF4, B-TG or TBXB2 in patients with and without major depression. Results were unchanged after adjustment for age, smoking, use of aspirin, and use of any psychotropic medication. We found no evidence of an association between major depression and platelet activation as measured by plasma concentrations of PF4 and β-TG, or urinary TBXB2 in 104 outpatients with stable CHD. These findings do not support a role for platelet activation in the association between depression and cardiovascular disease among patients with stable CHD.
AB - Depression is associated with increased morbidity and mortality in patients with coronary heart disease (CHD). Increased platelet activation has been proposed as a potential mechanism by which depression may lead to adverse cardiovascular outcomes. In this cross-sectional study, we measured platelet activation in 104 patients with stable CHD, including 58 with a current episode of major depression and 46 without past or current major depression. Participants were instructed not to take aspirin for 7 days prior to the study appointment. Platelet activation was measured by plasma concentrations of platelet factor 4 (PF4) and beta-thromboglobulin (β-TG), and by 24-h urinary concentrations of 11-dehydro-thromboxane B2 (TBXB2). We observed no differences in the mean levels of PF4, B-TG or TBXB2 in patients with and without major depression. Results were unchanged after adjustment for age, smoking, use of aspirin, and use of any psychotropic medication. We found no evidence of an association between major depression and platelet activation as measured by plasma concentrations of PF4 and β-TG, or urinary TBXB2 in 104 outpatients with stable CHD. These findings do not support a role for platelet activation in the association between depression and cardiovascular disease among patients with stable CHD.
KW - Coronary heart disease
KW - Depression
KW - Mechanisms
KW - Platelet activation
UR - http://www.scopus.com/inward/record.url?scp=73449148992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73449148992&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2009.01.010
DO - 10.1016/j.psychres.2009.01.010
M3 - Article
C2 - 20034674
AN - SCOPUS:73449148992
VL - 175
SP - 200
EP - 204
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 3
ER -