Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis

Jeffrey S. Gonzalez, Abigail W. Batchelder, Christina Psaros, Steven Safren

Research output: Contribution to journalReview article

378 Scopus citations

Abstract

We meta-analyzed the relationship between depression and HIV medication nonadherence to calculate the overall effect size and examine potential moderators. Overall, across 95 independent samples, depression was significantly (P < 0.0001) associated with nonadherence (r = 0.19; 95% confidence interval = 0.14 to 0.25). Studies evaluating medication adherence via interview found significantly larger effects than those using self-administered questionnaires. Studies measuring adherence along a continuum found significantly stronger effects than studies comparing dichotomies. Effect size was not significantly related to other aspects of adherence or depression measurement, assessment interval (ie, cross-sectional vs. longitudinal), sex, IV drug use, sexual orientation, or study location. The relationship between depression and HIV treatment nonadherence is consistent across samples and over time, is not limited to those with clinical depression, and is not inflated by self-report bias. Our results suggest that interventions aimed at reducing depressive symptom severity, even at subclinical levels, should be a behavioral research priority.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume58
Issue number2
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

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Keywords

  • adherence
  • compliance
  • depression
  • HIV/AIDS
  • meta-analysis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

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