Abstract
Depression is the most common psychiatric comorbidity in people with epilepsy, but it remains underrecognized and undertreated. In addition to its negative impact on quality of life, depressive disorders are predictive of a worse response to pharmacologic and surgical treatment of seizure disorders. This phenomenon is probably an expression of a bidirectional relationship between epilepsy and depression, which in turn is indicative of common pathogenic mechanisms that are operant in the two conditions. The abnormal role of the hypothalamic-pituitary-adrenal axis is one of the common pathogenic mechanisms that explains why patients with depression are at greater risk for developing epilepsy and vice versa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-312 |
| Number of pages | 6 |
| Journal | Current Neurology and Neuroscience Reports |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Depression and epilepsy : Do glucocorticoids and glutamate explain their relationship? / Kanner, Andres M.
In: Current Neurology and Neuroscience Reports, Vol. 9, No. 4, 07.2009, p. 307-312.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression and epilepsy
T2 - Do glucocorticoids and glutamate explain their relationship?
AU - Kanner, Andres M
PY - 2009/7
Y1 - 2009/7
N2 - Depression is the most common psychiatric comorbidity in people with epilepsy, but it remains underrecognized and undertreated. In addition to its negative impact on quality of life, depressive disorders are predictive of a worse response to pharmacologic and surgical treatment of seizure disorders. This phenomenon is probably an expression of a bidirectional relationship between epilepsy and depression, which in turn is indicative of common pathogenic mechanisms that are operant in the two conditions. The abnormal role of the hypothalamic-pituitary-adrenal axis is one of the common pathogenic mechanisms that explains why patients with depression are at greater risk for developing epilepsy and vice versa.
AB - Depression is the most common psychiatric comorbidity in people with epilepsy, but it remains underrecognized and undertreated. In addition to its negative impact on quality of life, depressive disorders are predictive of a worse response to pharmacologic and surgical treatment of seizure disorders. This phenomenon is probably an expression of a bidirectional relationship between epilepsy and depression, which in turn is indicative of common pathogenic mechanisms that are operant in the two conditions. The abnormal role of the hypothalamic-pituitary-adrenal axis is one of the common pathogenic mechanisms that explains why patients with depression are at greater risk for developing epilepsy and vice versa.
UR - http://www.scopus.com/inward/record.url?scp=67651225575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67651225575&partnerID=8YFLogxK
U2 - 10.1007/s11910-009-0046-1
DO - 10.1007/s11910-009-0046-1
M3 - Article
C2 - 19515283
AN - SCOPUS:67651225575
VL - 9
SP - 307
EP - 312
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
SN - 1528-4042
IS - 4
ER -