Abstract
Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 865-880 |
| Number of pages | 16 |
| Journal | Neurologic Clinics |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 2009 |
| Externally published | Yes |
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Keywords
- Anxiety disorders
- Frontal lobe epilepsy
- Hippocampal atrophy
- Major depressive disorder
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Depression and Epilepsy : A Review of Multiple Facets of Their Close Relation. / Kanner, Andres M.
In: Neurologic Clinics, Vol. 27, No. 4, 11.2009, p. 865-880.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression and Epilepsy
T2 - A Review of Multiple Facets of Their Close Relation
AU - Kanner, Andres M
PY - 2009/11
Y1 - 2009/11
N2 - Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.
AB - Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.
KW - Anxiety disorders
KW - Frontal lobe epilepsy
KW - Hippocampal atrophy
KW - Major depressive disorder
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=70350062088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350062088&partnerID=8YFLogxK
U2 - 10.1016/j.ncl.2009.08.002
DO - 10.1016/j.ncl.2009.08.002
M3 - Article
VL - 27
SP - 865
EP - 880
JO - Neurologic Clinics
JF - Neurologic Clinics
SN - 0733-8619
IS - 4
ER -