Depression and Epilepsy

A Review of Multiple Facets of Their Close Relation

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.

Original languageEnglish (US)
Pages (from-to)865-880
Number of pages16
JournalNeurologic Clinics
Volume27
Issue number4
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Epilepsy
Depressive Disorder
Depression
Psychiatry
Frontal Lobe
Temporal Lobe
Nervous System Diseases
Comorbidity
Seizures
Quality of Life

Keywords

  • Anxiety disorders
  • Frontal lobe epilepsy
  • Hippocampal atrophy
  • Major depressive disorder
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Depression and Epilepsy : A Review of Multiple Facets of Their Close Relation. / Kanner, Andres M.

In: Neurologic Clinics, Vol. 27, No. 4, 11.2009, p. 865-880.

Research output: Contribution to journalArticle

@article{35dc487d627e4e1ab14d679f41267ace,
title = "Depression and Epilepsy: A Review of Multiple Facets of Their Close Relation",
abstract = "Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.",
keywords = "Anxiety disorders, Frontal lobe epilepsy, Hippocampal atrophy, Major depressive disorder, Temporal lobe epilepsy",
author = "Kanner, {Andres M}",
year = "2009",
month = "11",
doi = "10.1016/j.ncl.2009.08.002",
language = "English (US)",
volume = "27",
pages = "865--880",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Depression and Epilepsy

T2 - A Review of Multiple Facets of Their Close Relation

AU - Kanner, Andres M

PY - 2009/11

Y1 - 2009/11

N2 - Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.

AB - Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.

KW - Anxiety disorders

KW - Frontal lobe epilepsy

KW - Hippocampal atrophy

KW - Major depressive disorder

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=70350062088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350062088&partnerID=8YFLogxK

U2 - 10.1016/j.ncl.2009.08.002

DO - 10.1016/j.ncl.2009.08.002

M3 - Article

VL - 27

SP - 865

EP - 880

JO - Neurologic Clinics

JF - Neurologic Clinics

SN - 0733-8619

IS - 4

ER -