Depression and epilepsy: A bidirectional relation?

Research output: Contribution to journalArticle

125 Scopus citations


A bidirectional relation between depressive disorders and epilepsy has been suggested by several population-based studies and is supported by experimental studies. This article reviews the potential pathogenic mechanisms operant in both disorders that may explain such a relation. These mechanisms include a hyperactive hypothalamic-pituitary-adrenal (HPA) axis and its neuroanatomic and neuropathologic complications, as well as disturbances in serotonergic, noradrenergic, γ-aminobutyric acid (GABA)ergic and glutamatergic neurotransmitter systems, all of which may be interrelated.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
Issue numberSUPPL. 1
StatePublished - Jan 1 2011
Externally publishedYes


  • Attention deficit hyperactivity disorder
  • Depression
  • Glutamate
  • Norepinephrine
  • Serotonin
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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