Depression and anxiety in adolescents and adults with cystic fibrosis in the UK: A cross-sectional study

Alistair J.A. Duff, Janice Abbott, Carolyn Cowperthwaite, Clare Sumner, Margaret A. Hurley, Alexandra Quittner

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Background: The International Depression/anxiety Epidemiological Study (TIDES) in the UK aimed: (i) to establish the prevalence of anxiety and depression amongst people with CF compared to a normative sample; (ii) to establish the association between mood, demographic and clinical variables; and (iii) to provide guidance for specialist-referral decision-making. Methods: Patients (≥. 12. years) completed the Hospital Anxiety and Depression Scale (HADS). CF-HADS scores, expressed as percentiles, were compared with a normative sample. Multiple-regression analysis explored associations between demographic, clinical and mood variables. Results: Thirty-nine CF centres recruited 2065 patients. Adults with CF were similar in terms of anxiety and depression to the general population. Adolescents with CF were less anxious and depressed. For adult patients, older age, unemployment for health reasons and poor lung function were associated with disordered mood. Gender-specific CF-percentile scores were calculated. Conclusion: Surveillance, with attention to gender and risk factors is advocated. This work provides unique benchmark scores to aid referral decision-making.

Original languageEnglish (US)
Pages (from-to)745-753
Number of pages9
JournalJournal of Cystic Fibrosis
Issue number6
StatePublished - Dec 1 2014
Externally publishedYes


  • Anxiety
  • Cystic fibrosis
  • Depression
  • HADS
  • Management
  • Prevalence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health


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