Depression, alterations in platelet function, and ischemic heart disease

Erica C. Bruce, Dominique Musselman

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Platelets, the smallest corpuscular component of human blood, are central to various crucial biologic pathways in the human body. Diminished platelet function is thought to contribute to the increased risk of ischemic heart disease in patients with major depressive disorder, and to the increased morbidity and diminished survival of depressed patients after an index myocardial infarction. We reviewed both recent studies that evaluated platelet function in various patient groups and recent information regarding the potential beneficial effects of selective serotonin reuptake inhibitors on platelet reactivity.

Original languageEnglish
JournalPsychosomatic Medicine
Volume67
Issue numberSUPPL. 1
DOIs
StatePublished - May 1 2005
Externally publishedYes

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Myocardial Ischemia
Blood Platelets
Depression
Major Depressive Disorder
Serotonin Uptake Inhibitors
Human Body
Myocardial Infarction
Morbidity
Survival

Keywords

  • Depression
  • Ischemic heart disease
  • Platelet dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Depression, alterations in platelet function, and ischemic heart disease. / Bruce, Erica C.; Musselman, Dominique.

In: Psychosomatic Medicine, Vol. 67, No. SUPPL. 1, 01.05.2005.

Research output: Contribution to journalArticle

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