Depression, alterations in platelet function, and ischemic heart disease

Erica C. Bruce, Dominique L. Musselman

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations


Platelets, the smallest corpuscular component of human blood, are central to various crucial biologic pathways in the human body. Diminished platelet function is thought to contribute to the increased risk of ischemic heart disease in patients with major depressive disorder, and to the increased morbidity and diminished survival of depressed patients after an index myocardial infarction. We reviewed both recent studies that evaluated platelet function in various patient groups and recent information regarding the potential beneficial effects of selective serotonin reuptake inhibitors on platelet reactivity.

Original languageEnglish (US)
Pages (from-to)S34-S36
JournalPsychosomatic medicine
Issue numberSUPPL. 1
StatePublished - May 2005
Externally publishedYes


  • Depression
  • Ischemic heart disease
  • Platelet dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)


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