Steven T. Szabo, Charles B. Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Depression is a devastating neurobiological disorder shaped by environmental stressors with profound societal impact. Not only is depression a primary mood disorder, it is commonly found in patients with other psychiatric and general medical illnesses, leading to considerable morbidity and mortality. Research into the underpinnings and treatments of depression have traditionally centered on understanding the pharmacological effects of medications that were largely discovered through serendipity. Advances in genetics, cellular and molecular biology, and brain imaging are providing the necessary tools to elucidate the complex and numerous etiologies of depression and potentials for treatment. Evolution of nonmedication (both psychotherapy and device-based treatments) occurring concurrently with the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) updates of the diagnostic criteria for depression auger a more precise understanding of this disease and its treatment. Characterizing specific and validated endophenotypes of depression will rely on gains made through scientific advances. The development of clinical biomarkers of depressive endophenotypes should allow for the development of both novel diagnostic tests, as well as predictors of treatment response-true personalized medicine.

Original languageEnglish (US)
Title of host publicationRosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Number of pages22
ISBN (Electronic)9780124105294
ISBN (Print)9780124105492
StatePublished - Nov 13 2014


  • Brain circuitry
  • Molecular genetics
  • Neurotransmitters
  • Pathophysiology
  • Treatments

ASJC Scopus subject areas

  • Medicine(all)


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