Depressed neurofilament expression associates with apolipoprotein E3/E4 genotype in maturing human fetal neurons exposed to HIV-1

Ricardo Martinez, Wu Chunjing, Rebeca Geffin, Micheline McCarthy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Exposure of differentiating human neural progenitor cells (NEP) to HIV-1 results in a neuronal "failure to thrive" phenotype characterized by a relative decrease in neurofilament-light (NF-L) expression. However, when NEP were segregated by their apolipoprotein E genotype, differentiating apolipoprotein E3/E4 cells showed reduced NF-L expression upon HIV-1 exposure, but differentiating apolipoprotein E3/E3 or apolipopro-tein E4/E4 cells did not. These data suggest that apoli-poprotein E genotype is a host factor that could affect the development of neurocognitive dysfunction in HIV-1 infected individuals.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalJournal of neurovirology
Volume18
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • Apolipoprotein E
  • HIV
  • Neuroepithelial progenitor cells
  • Neurofilament protein-light

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

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