Exposure of differentiating human neural progenitor cells (NEP) to HIV-1 results in a neuronal "failure to thrive" phenotype characterized by a relative decrease in neurofilament-light (NF-L) expression. However, when NEP were segregated by their apolipoprotein E genotype, differentiating apolipoprotein E3/E4 cells showed reduced NF-L expression upon HIV-1 exposure, but differentiating apolipoprotein E3/E3 or apolipopro-tein E4/E4 cells did not. These data suggest that apoli-poprotein E genotype is a host factor that could affect the development of neurocognitive dysfunction in HIV-1 infected individuals.
- Apolipoprotein E
- Neuroepithelial progenitor cells
- Neurofilament protein-light
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience