Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle

Jay R. Wiggins, Henry Gelband, Arthur L. Bassett

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalEuropean Journal of Pharmacology
Volume59
Issue number1-2
DOIs
StatePublished - Oct 26 1979

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Keywords

  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine
  • Potassium contracture
  • Ventricular muscle

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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