Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle

Jay R. Wiggins; Henry Gelband; Arthur L. Bassett

doi:10.1016/0014-2999(79)90031-1

Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle

Jay R. Wiggins, Henry Gelband, Arthur L. Bassett

Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Phenoxybenzamine has been shown to have a depressant action on K⁺-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K⁺-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	European Journal of Pharmacology
Volume	59
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(79)90031-1
State	Published - Oct 26 1979

Keywords

Phenoxybenzamine
Phentolamine
Phenylephrine
Potassium contracture
Ventricular muscle

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(79)90031-1

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title = "Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle",

abstract = "Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.",

keywords = "Phenoxybenzamine, Phentolamine, Phenylephrine, Potassium contracture, Ventricular muscle",

author = "Wiggins, {Jay R.} and Henry Gelband and Bassett, {Arthur L.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (HL-22685, HL-19044) and Grants-in-Aid from the American Heart Association, Suncoast and Greater Miami Affiliates.",

year = "1979",

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T1 - Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle

AU - Wiggins, Jay R.

AU - Gelband, Henry

AU - Bassett, Arthur L.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (HL-22685, HL-19044) and Grants-in-Aid from the American Heart Association, Suncoast and Greater Miami Affiliates.

PY - 1979/10/26

Y1 - 1979/10/26

N2 - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.

AB - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.

KW - Phenoxybenzamine

KW - Phentolamine

KW - Phenylephrine

KW - Potassium contracture

KW - Ventricular muscle

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