Abstract
Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 111-114 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 59 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 26 1979 |
| Externally published | Yes |
Fingerprint
Keywords
- Phenoxybenzamine
- Phentolamine
- Phenylephrine
- Potassium contracture
- Ventricular muscle
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle. / Wiggins, Jay R.; Gelband, Henry; Bassett, Arthur L.
In: European Journal of Pharmacology, Vol. 59, No. 1-2, 26.10.1979, p. 111-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle
AU - Wiggins, Jay R.
AU - Gelband, Henry
AU - Bassett, Arthur L.
PY - 1979/10/26
Y1 - 1979/10/26
N2 - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.
AB - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.
KW - Phenoxybenzamine
KW - Phentolamine
KW - Phenylephrine
KW - Potassium contracture
KW - Ventricular muscle
UR - http://www.scopus.com/inward/record.url?scp=0018652250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018652250&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(79)90031-1
DO - 10.1016/0014-2999(79)90031-1
M3 - Article
C2 - 510392
AN - SCOPUS:0018652250
VL - 59
SP - 111
EP - 114
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -