Abstract
Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.
Original language | English (US) |
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Pages (from-to) | 111-114 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 59 |
Issue number | 1-2 |
DOIs | |
State | Published - Oct 26 1979 |
Keywords
- Phenoxybenzamine
- Phentolamine
- Phenylephrine
- Potassium contracture
- Ventricular muscle
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology