Depolarization- and ionophore-induced release of octacosa somatostatin from stalk median eminence synaptosomes

C. F. Kewley, R. P. Millar, M. C. Berman, A. V. Schally

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Species of somatostatin of higher molecular weight were present in the nerve terminals (synaptosomes) of ovine stalk median eminences and were released by depolarizing stimuli. One of these species was identified as the biologically active molecule octacosa somatostatin. Octacosa somatostatin appears therefore to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.

Original languageEnglish (US)
Pages (from-to)913-915
Number of pages3
JournalScience
Volume213
Issue number4510
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Depolarization- and ionophore-induced release of octacosa somatostatin from stalk median eminence synaptosomes'. Together they form a unique fingerprint.

  • Cite this