Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus

Kouichi Itoh, Ken Shimono, Vance Lemmon

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The neural cell adhesion molecule L1 may participate in initiating and maintaining synaptic changes during learning in the hippocampus. One prominent form of synaptic change in the hippocampus is long-term potentiation (LTP) that occurs following specific patterns of synaptic activity. We present evidence that Y1176 of the YRSL motif within L1 cytoplasmic domain is dephosphorylated in LTP-induced hippocampus. The dephosphorylated L1 is associated with AP-2 and AP180 that are required for clathrin-mediated internalization of L1. These data suggest that clathrin-mediated recycling of L1 at presynaptic sites is enhanced by certain kinds of neural activity, and that maintenance of LTP-induced synaptic changes is regulated by L1 recycling.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalMolecular and Cellular Neuroscience
Volume29
Issue number2
DOIs
StatePublished - Jun 1 2005

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Neural Cell Adhesion Molecule L1
Long-Term Potentiation
Hippocampus
Clathrin
Recycling
Maintenance
Learning

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus. / Itoh, Kouichi; Shimono, Ken; Lemmon, Vance.

In: Molecular and Cellular Neuroscience, Vol. 29, No. 2, 01.06.2005, p. 245-249.

Research output: Contribution to journalArticle

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