Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces

P. D. Drumheller, J. A. Hubbell

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Densely crosslinked semi-interpenetrating polymer networks (semi-IPNs) of poly(ethylene glycol) (PEG) were synthesized by photopolymerizing a melt of PEG of various molecular weights and end-group functionalities in neat trimethylolpropane triacrylate (TMPTA). Increasing the molecular weight of PEG in the matrix from 1000 to 100,000 g/mol reduced the advancing and receding contact angles, contact angle hysteresis, and adsorption of human fibrinogen and bovine serum albumin. Crosslinked TMPTA homonetworks supported human fibroblast adhesion in vitro, whereas the resistance to cell adhesion of the semi-IPNs depended upon PEG molecular weight: Lower molecular weight PEG reduced the number of adherent cells; higher molecular weight PEG further reduced and eliminated cell adhesion, as did networks containing, acrylate- functionalized PEG. A polymer system incorporated with PEG throughout a hydrophobic, densely crosslinked matrix, rather than as a blend or surface treatment, may be particularly useful for limiting biologic interactions when bulk material properties must be independent of the solvent environment and where surface abrasion may occur.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalJournal of Biomedical Materials Research
Volume29
Issue number2
DOIs
StatePublished - Feb 1 1995
Externally publishedYes

Fingerprint

Cell adhesion
Polyethylene glycols
Polymers
Molecular weight
Interpenetrating polymer networks
Contact angle
trimethylolpropane triacrylate
Fibroblasts
Bovine Serum Albumin
Abrasion
Fibrinogen
Hysteresis
Surface treatment
Materials properties
Adhesion
Adsorption

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces. / Drumheller, P. D.; Hubbell, J. A.

In: Journal of Biomedical Materials Research, Vol. 29, No. 2, 01.02.1995, p. 207-215.

Research output: Contribution to journalArticle

@article{0d2191a68fa44a20baab1ba805472c47,
title = "Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces",
abstract = "Densely crosslinked semi-interpenetrating polymer networks (semi-IPNs) of poly(ethylene glycol) (PEG) were synthesized by photopolymerizing a melt of PEG of various molecular weights and end-group functionalities in neat trimethylolpropane triacrylate (TMPTA). Increasing the molecular weight of PEG in the matrix from 1000 to 100,000 g/mol reduced the advancing and receding contact angles, contact angle hysteresis, and adsorption of human fibrinogen and bovine serum albumin. Crosslinked TMPTA homonetworks supported human fibroblast adhesion in vitro, whereas the resistance to cell adhesion of the semi-IPNs depended upon PEG molecular weight: Lower molecular weight PEG reduced the number of adherent cells; higher molecular weight PEG further reduced and eliminated cell adhesion, as did networks containing, acrylate- functionalized PEG. A polymer system incorporated with PEG throughout a hydrophobic, densely crosslinked matrix, rather than as a blend or surface treatment, may be particularly useful for limiting biologic interactions when bulk material properties must be independent of the solvent environment and where surface abrasion may occur.",
author = "Drumheller, {P. D.} and Hubbell, {J. A.}",
year = "1995",
month = "2",
day = "1",
doi = "10.1002/jbm.820290211",
language = "English",
volume = "29",
pages = "207--215",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "1549-3296",
publisher = "Heterocorporation",
number = "2",

}

TY - JOUR

T1 - Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces

AU - Drumheller, P. D.

AU - Hubbell, J. A.

PY - 1995/2/1

Y1 - 1995/2/1

N2 - Densely crosslinked semi-interpenetrating polymer networks (semi-IPNs) of poly(ethylene glycol) (PEG) were synthesized by photopolymerizing a melt of PEG of various molecular weights and end-group functionalities in neat trimethylolpropane triacrylate (TMPTA). Increasing the molecular weight of PEG in the matrix from 1000 to 100,000 g/mol reduced the advancing and receding contact angles, contact angle hysteresis, and adsorption of human fibrinogen and bovine serum albumin. Crosslinked TMPTA homonetworks supported human fibroblast adhesion in vitro, whereas the resistance to cell adhesion of the semi-IPNs depended upon PEG molecular weight: Lower molecular weight PEG reduced the number of adherent cells; higher molecular weight PEG further reduced and eliminated cell adhesion, as did networks containing, acrylate- functionalized PEG. A polymer system incorporated with PEG throughout a hydrophobic, densely crosslinked matrix, rather than as a blend or surface treatment, may be particularly useful for limiting biologic interactions when bulk material properties must be independent of the solvent environment and where surface abrasion may occur.

AB - Densely crosslinked semi-interpenetrating polymer networks (semi-IPNs) of poly(ethylene glycol) (PEG) were synthesized by photopolymerizing a melt of PEG of various molecular weights and end-group functionalities in neat trimethylolpropane triacrylate (TMPTA). Increasing the molecular weight of PEG in the matrix from 1000 to 100,000 g/mol reduced the advancing and receding contact angles, contact angle hysteresis, and adsorption of human fibrinogen and bovine serum albumin. Crosslinked TMPTA homonetworks supported human fibroblast adhesion in vitro, whereas the resistance to cell adhesion of the semi-IPNs depended upon PEG molecular weight: Lower molecular weight PEG reduced the number of adherent cells; higher molecular weight PEG further reduced and eliminated cell adhesion, as did networks containing, acrylate- functionalized PEG. A polymer system incorporated with PEG throughout a hydrophobic, densely crosslinked matrix, rather than as a blend or surface treatment, may be particularly useful for limiting biologic interactions when bulk material properties must be independent of the solvent environment and where surface abrasion may occur.

UR - http://www.scopus.com/inward/record.url?scp=0029239634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029239634&partnerID=8YFLogxK

U2 - 10.1002/jbm.820290211

DO - 10.1002/jbm.820290211

M3 - Article

C2 - 7738068

AN - SCOPUS:0029239634

VL - 29

SP - 207

EP - 215

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 1549-3296

IS - 2

ER -