Dense hydroxylation (HA) and microporous HA resorption

Andrw J. Tofe, Barbara A. Watson, Herman S. Cheung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In this presentation, the density and porosity of commercially available hydroxylapatite (HA) bone grafting materials analyzed by scanning electron microscopy (SEM). The calcium phosphate phases and molecular constituents responsible for dissolution/ resorption of hydroxylapatite (HA) were analyzed by x-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopy. The lack of microporosity explains the nonresorptive nature of truly dense HA while the presence of microporosity leads to cell-mediated resorption. The latter was evaluated using the in vitro cell culture model with human fibroblasts. Scanning electron and light microscopy confirmed the endocytosis mechanism for porous HA and illustrated the inhibition of cellular invasion/resorption by dense HA. A multi-analytical /spectroscopic approach coupled to in vitro cell culture studies provides insight into the dissolution/resorption of HA grafting materials and HA coating on implants.

Original languageEnglish (US)
Title of host publicationProceedings of the Symposium on Characterization and Performance of Calcium Phosphate Coatings for Implants
EditorsEmanuel Horowitz, Jack E. Parr
PublisherPubl by ASTM
Pages163-169
Number of pages7
ISBN (Print)0803118546
StatePublished - Dec 1 1994
Externally publishedYes
EventProceedings of the Symposium on Characterization and Performance of Calcium Phoshate Coatings for Implants - Miami, FL, USA
Duration: Nov 17 1992Nov 17 1992

Publication series

NameProceedings of the Symposium on Characterization and Performance of Calcium Phosphate Coatings for Implants

Other

OtherProceedings of the Symposium on Characterization and Performance of Calcium Phoshate Coatings for Implants
CityMiami, FL, USA
Period11/17/9211/17/92

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Tofe, A. J., Watson, B. A., & Cheung, H. S. (1994). Dense hydroxylation (HA) and microporous HA resorption. In E. Horowitz, & J. E. Parr (Eds.), Proceedings of the Symposium on Characterization and Performance of Calcium Phosphate Coatings for Implants (pp. 163-169). (Proceedings of the Symposium on Characterization and Performance of Calcium Phosphate Coatings for Implants). Publ by ASTM.