Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER

Guido Boehmelt, Jaime Madruga, Petra Dörfler, Karoline Briegel, Heinz Schwarz, Paula J. Enrietto, Martin Zenke

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

A conditional v-Rel estrogen receptor fusion protein, v-RelER, causes estrogen-dependent but otherwise unaltered v-rel-specific transformation of chicken bone marrow cells. Here, we demonstrate that such v-relER-transformed cells exhibit B lymphoid determinants in line with earlier studies on v-rel- transformed cells. However, following inactivation of v-RelER oncoprotein activity by administration of an estrogen antagonist, cells differentiate into antigen-presenting dendritic cells as judged by several morphological and functional criteria. Additionally, under yet different culture conditions, v-relER cells differentiate into cells resembling polymorphonuclear neutrophils. Our studies therefore suggest that the conditional v-Rel ER, and probably also the authentic v-Rel, transform a common progenitor for neutrophils and dendritic cells.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
JournalCell
Volume80
Issue number2
DOIs
StatePublished - Feb 16 1995
Externally publishedYes

Fingerprint

Estrogen Receptors
Dendritic Cells
Fusion reactions
Estrogen Antagonists
Oncogene Proteins
Bone
Estrogens
Proteins
Cells
Antigens
Neutrophils
Antigen-Presenting Cells
Bone Marrow Cells
Chickens
Stem Cells
estrophilin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Boehmelt, G., Madruga, J., Dörfler, P., Briegel, K., Schwarz, H., Enrietto, P. J., & Zenke, M. (1995). Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER. Cell, 80(2), 341-352. https://doi.org/10.1016/0092-8674(95)90417-4

Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER. / Boehmelt, Guido; Madruga, Jaime; Dörfler, Petra; Briegel, Karoline; Schwarz, Heinz; Enrietto, Paula J.; Zenke, Martin.

In: Cell, Vol. 80, No. 2, 16.02.1995, p. 341-352.

Research output: Contribution to journalArticle

Boehmelt, G, Madruga, J, Dörfler, P, Briegel, K, Schwarz, H, Enrietto, PJ & Zenke, M 1995, 'Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER', Cell, vol. 80, no. 2, pp. 341-352. https://doi.org/10.1016/0092-8674(95)90417-4
Boehmelt, Guido ; Madruga, Jaime ; Dörfler, Petra ; Briegel, Karoline ; Schwarz, Heinz ; Enrietto, Paula J. ; Zenke, Martin. / Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER. In: Cell. 1995 ; Vol. 80, No. 2. pp. 341-352.
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