Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-ReIER

Guido Boehmelt, Jaime Madruga, Petra Ddrfler, Karoline Briegel, Heinz Schwarz, Paula J. Enrietto, Martin Zenke

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

A conditional v-Rel estrogen receptor fusion protein, v-RelER, causes estrogen-dependent but otherwise unaltered v-rel-specific transformation of chicken bone marrow cells. Here, we demonstrate that such v-relER-transformed cells exhibit B lymphoid determinants in line with earlier studies on v-rel- transformed cells. However, following inactivation of v-RelER oncoprotein activity by administration of an estrogen antagonist, cells differentiate into antigen-presenting dendritic cells as judged by several morphological and functional criteria. Additionally, under yet different culture conditions, v-relER cells differentiate into cells resembling polymorphonuclear neutrophils. Our studies therefore suggest that the conditional v-Rel ER, and probably also the authentic v-Rel, transform a common progenitor for neutrophils and dendritic cells.

Original languageEnglish (US)
Pages (from-to)341-352
Number of pages12
JournalCell
Volume80
Issue number2
DOIs
StatePublished - Jan 27 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Boehmelt, G., Madruga, J., Ddrfler, P., Briegel, K., Schwarz, H., Enrietto, P. J., & Zenke, M. (1995). Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-ReIER. Cell, 80(2), 341-352. https://doi.org/10.1016/0092-8674(95)90417-4