Dendrimers and their pharmaceutical applications - A review

Inderbir Singh, A. K. Rehni, R. Kalra, G. Joshi, M. Kumar

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Dendrimers are hyperbranched macromolecules having tree like structure, consisting of a core molecule and alternating layers of monomers. They can be synthesized by divergent and convergent growth methods. During synthesis, properties like dendrimer size, molecular mass, surface group can be controlled and configured to the desired need. The ability of dendrimers to encapsulate and bind the guest molecule can be used for solubility enhancement, sustained release and drug delivery applications. In this review we tried to delineate the properties, synthesis methods and expound potential pharmaceutical applications along with toxicological considerations of dendrimers.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalPharmazie
Volume63
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science

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