Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury

J. D. Guest, E. D. Hiester, R. P. Bunge

Research output: Contribution to journalArticlepeer-review

226 Scopus citations


The natural history of post-traumatic demyelination and myelin repair in the human spinal cord is largely unknown and has remained a matter of speculation. A wealth of experimental studies indicate that mild to moderate contusive injuries to the mammalian spinal cord evolve into a cavity with a preserved rim of white matter in which a population of segmentally demyelinated axons persists. It is believed that such injured axons have abnormal conduction properties. Theoretically, such axons might show improved function if myelin repair occurred. Schwann cells can remyelinate axons affected by multiple sclerosis, but little evidence exists that such repair can occur spontaneously following traumatic human SCI. Therefore, it is important to determine if chronic demyelination is present following human spinal cord injury. There are no previous reports that have conclusively demonstrated demyelination in the human spinal cord following traumatic spinal cord injury using immunohistochemical techniques. Immunohistochemical methods were used to study the distribution of peripheral and central myelin proteins as well as axonal neurofilament at the injury epicenter in 13 postmortem chronically injured human spinal cords 1-22 years following injury. Of these seven could be assessed by our methods. We found that some axonal demyelination can be detected even a decade following human SCI and indirect evidence that invading Schwann cells contributed to restoration of myelin sheaths around some spinal axons.

Original languageEnglish (US)
Pages (from-to)384-393
Number of pages10
JournalExperimental neurology
Issue number2
StatePublished - Apr 2005


  • Demyelination
  • Human
  • Schwann cell
  • Schwannosis
  • Spinal cord injury

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)


Dive into the research topics of 'Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury'. Together they form a unique fingerprint.

Cite this