Demyelinating neuropathy in diabetes mellitus

Khema R Sharma, John Cross, Oscar Farronay, D. Ram Ayyar, Robert T. Shebert, Walter G Bradley

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Background: Recent studies have reported that patients with diabetes mellitus (DM) have a predisposition to develop chronic inflammatory demyelinating polyneuropathy (CIDP). Objectives: To determine whether patients with DM have a polyneuropathy fulfilling electrophysiologic criteria for CIDP, and whether CIDP is more frequent in patients with type 1 than in patients with type 2 DM. Methods: We prospectively studied the frequency of electrophysiologic changes meeting the criteria for CIDP in patients with DM seen in our electrophysiology laboratory during a 51-month period (period 1). To evaluate the relationship between DM and CIDP, we prospectively determined during a 14-month period (period 2) the frequency of DM in patients seen in our electrophysiology laboratory with other neuromuscular diseases, and the frequency of idiopathic CIDP. Results: During period 1,120 patients with DM met the electrophysiologic criteria for CIDP (DM-CIDP). The most frequent clinical features of DM-CIDP were those of a predominantly large-fiber sensorimotor neuropathy, with recent motor deterioration and a moderately increased cerebrospinal fluid protein concentration. Twenty-six of the 120 patients were given intravenous immunoglobulin (400 mg/kg per day for 5 days), and 21 patients (80.8%) had significant improvement in the neurologic deficit at the end of 4 weeks of therapy. The DM-CIDP occurred equally in type 1 and type 2 DM. During period 2, 1127 patients were seen. Of these, 189 (16.8%) had DM with various neurologic disorders, including 32 patients (16.9%) with DM-CIDP. Among the remaining 938 patients without DM, 17 (1.8%) had idiopathic CIDP. The odds of occurrence of DM-CIDP was 11 times higher among diabetic than nondiabetic patients P<.001). Conclusions: Demyelinating neuropathy meeting the electrophysiologic criteria for CIDP occurred in both types of DM, and its occurrence was significantly higher in diabetic than in nondiabetic patients.

Original languageEnglish
Pages (from-to)758-765
Number of pages8
JournalArchives of Neurology
Volume59
Issue number5
StatePublished - May 27 2002

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Diabetes Mellitus
Electrophysiology
Type 2 Diabetes Mellitus
Cerebrospinal Fluid Proteins
Neuromuscular Diseases
Polyneuropathies
Intravenous Immunoglobulins
Neurologic Manifestations
Nervous System Diseases
Type 1 Diabetes Mellitus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sharma, K. R., Cross, J., Farronay, O., Ayyar, D. R., Shebert, R. T., & Bradley, W. G. (2002). Demyelinating neuropathy in diabetes mellitus. Archives of Neurology, 59(5), 758-765.

Demyelinating neuropathy in diabetes mellitus. / Sharma, Khema R; Cross, John; Farronay, Oscar; Ayyar, D. Ram; Shebert, Robert T.; Bradley, Walter G.

In: Archives of Neurology, Vol. 59, No. 5, 27.05.2002, p. 758-765.

Research output: Contribution to journalArticle

Sharma, KR, Cross, J, Farronay, O, Ayyar, DR, Shebert, RT & Bradley, WG 2002, 'Demyelinating neuropathy in diabetes mellitus', Archives of Neurology, vol. 59, no. 5, pp. 758-765.
Sharma KR, Cross J, Farronay O, Ayyar DR, Shebert RT, Bradley WG. Demyelinating neuropathy in diabetes mellitus. Archives of Neurology. 2002 May 27;59(5):758-765.
Sharma, Khema R ; Cross, John ; Farronay, Oscar ; Ayyar, D. Ram ; Shebert, Robert T. ; Bradley, Walter G. / Demyelinating neuropathy in diabetes mellitus. In: Archives of Neurology. 2002 ; Vol. 59, No. 5. pp. 758-765.
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