Dementia with bilateral medial temporal lobe ischemia

Bruce T. Volpe, Carol K. Petito

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Neuropathologic examination of two patients with dementia showed chronic bilateral medial temporal lobe ischemic damage that included the hippocampus (particularly the CA-1 region), subiculum, and amygdala. Both patients had several myocardial infarctions, and the relatively circumscribed cerebral injury may have resulted from one or more episodes of global hypoxic ischemia. Focal hippocampal injury has been associated with amnesia. The additional damage to medial temporal lobe structures may have caused the dementia.

Original languageEnglish (US)
Pages (from-to)1793-1797
Number of pages5
JournalNeurology
Volume35
Issue number12
DOIs
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Clinical Neurology

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