Dementia and motor neuron disease: Morphometric, biochemical, and Golgi studies

D. S. Horoupian, L. Thal, R. Katzman, R. D. Terry, P. Davies, A. Hirano, R. DeTeresa, P. A. Fuld, Carol Petito, J. Blass

Research output: Contribution to journalArticle

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Abstract

In three patients dementia without neurofibrillary tangles or Pick bodies antedated amyotrophy by several years. The motor neuron disorder in two patients was characterized by terminal bulbar symptoms: in one it was similar to classic amyotrophic lateral sclerosis. In two patients, quantitative studies of selected regions of the cortex using a computerized image analyzer disclosed, as in patients with senile dementia of Alzheimer type, a marked reduction in the number of neurons, especially those larger than 90 μ2. The findings differed from those in Alzheimer dementia, however, in that the cells in the substantia innominata were not reduced and the levels of choline acetyltransferase and somatostatin-like immunoreactivity, determined in one patient, were within normal limits. A variable degree of sponginess of the upper layers of the cortex was attributed to attrition of pyramidal cell dendrites, observed in the one patient in whom Golgi study was successful. Because of severe degeneration of the substantia nigra in all three, the disease in these patients may represent a subset of motor neuron disease or a multisystem atrophy.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalAnnals of Neurology
Volume16
Issue number3
StatePublished - Nov 15 1984
Externally publishedYes

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Motor Neuron Disease
Dementia
Alzheimer Disease
Substantia Innominata
Multiple System Atrophy
Neurofibrillary Tangles
Choline O-Acetyltransferase
Pyramidal Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Substantia Nigra
Dendrites
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Horoupian, D. S., Thal, L., Katzman, R., Terry, R. D., Davies, P., Hirano, A., ... Blass, J. (1984). Dementia and motor neuron disease: Morphometric, biochemical, and Golgi studies. Annals of Neurology, 16(3), 305-313.

Dementia and motor neuron disease : Morphometric, biochemical, and Golgi studies. / Horoupian, D. S.; Thal, L.; Katzman, R.; Terry, R. D.; Davies, P.; Hirano, A.; DeTeresa, R.; Fuld, P. A.; Petito, Carol; Blass, J.

In: Annals of Neurology, Vol. 16, No. 3, 15.11.1984, p. 305-313.

Research output: Contribution to journalArticle

Horoupian, DS, Thal, L, Katzman, R, Terry, RD, Davies, P, Hirano, A, DeTeresa, R, Fuld, PA, Petito, C & Blass, J 1984, 'Dementia and motor neuron disease: Morphometric, biochemical, and Golgi studies', Annals of Neurology, vol. 16, no. 3, pp. 305-313.
Horoupian DS, Thal L, Katzman R, Terry RD, Davies P, Hirano A et al. Dementia and motor neuron disease: Morphometric, biochemical, and Golgi studies. Annals of Neurology. 1984 Nov 15;16(3):305-313.
Horoupian, D. S. ; Thal, L. ; Katzman, R. ; Terry, R. D. ; Davies, P. ; Hirano, A. ; DeTeresa, R. ; Fuld, P. A. ; Petito, Carol ; Blass, J. / Dementia and motor neuron disease : Morphometric, biochemical, and Golgi studies. In: Annals of Neurology. 1984 ; Vol. 16, No. 3. pp. 305-313.
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