Delivery of epilepsy care to adults with intellectual and developmental disabilities

Orrin Devinsky, Miya Asato, Peter Camfield, Eric Geller, Andres M Kanner, Seth Keller, Michael Kerr, Eric H. Kossoff, Heather Lau, Sanjeev Kothare, Baldev K. Singh, Elaine Wirrell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epilepsy, especially symptomatic generalized and treatment-resistant epilepsies. The causes of IDD-E are increasingly recognized to be genetic based on chromosomal microarray analysis to identify copy number variants, gene panels (epilepsy, autism spectrum disorder, intellectual disability), and whole-exome sequencing. A specific genetic diagnosis may guide care by pointing to comorbid disorders and best therapy. Therapy to control seizures should be individualized, with drug selection based on seizure types, epilepsy syndrome, concomitant medications, and comorbid disorders. There are limited comparative antiepileptic drug data in the IDD-E population. Vagus nerve and responsive neural stimulation therapies and resective surgery should be considered. Among the many comorbid disorders that affect patients with IDD-E, psychiatric and sleep disorders are common but often unrecognized and typically not treated. Transition from holistic and coordinated pediatric to adult care is often a vulnerable period. Communication among adult health care providers is complex but essential to ensure best care when these patients are seen in outpatient, emergency room, and inpatient settings. We propose specific recommendations for minimum care standards for people with IDD-E.

Original languageEnglish (US)
Pages (from-to)1512-1521
Number of pages10
JournalNeurology
Volume85
Issue number17
DOIs
StatePublished - Oct 27 2015

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Developmental Disabilities
Intellectual Disability
Epilepsy
Disabled Persons
Nervous System
Psychiatry
Seizures
Exome
Generalized Epilepsy
Vagus Nerve
Gene Dosage
Therapeutics
Microarray Analysis
Standard of Care
Health Personnel
Anticonvulsants
Hospital Emergency Service
Inpatients
Patient Care
Outpatients

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Devinsky, O., Asato, M., Camfield, P., Geller, E., Kanner, A. M., Keller, S., ... Wirrell, E. (2015). Delivery of epilepsy care to adults with intellectual and developmental disabilities. Neurology, 85(17), 1512-1521. https://doi.org/10.1212/WNL.0000000000002060

Delivery of epilepsy care to adults with intellectual and developmental disabilities. / Devinsky, Orrin; Asato, Miya; Camfield, Peter; Geller, Eric; Kanner, Andres M; Keller, Seth; Kerr, Michael; Kossoff, Eric H.; Lau, Heather; Kothare, Sanjeev; Singh, Baldev K.; Wirrell, Elaine.

In: Neurology, Vol. 85, No. 17, 27.10.2015, p. 1512-1521.

Research output: Contribution to journalArticle

Devinsky, O, Asato, M, Camfield, P, Geller, E, Kanner, AM, Keller, S, Kerr, M, Kossoff, EH, Lau, H, Kothare, S, Singh, BK & Wirrell, E 2015, 'Delivery of epilepsy care to adults with intellectual and developmental disabilities', Neurology, vol. 85, no. 17, pp. 1512-1521. https://doi.org/10.1212/WNL.0000000000002060
Devinsky, Orrin ; Asato, Miya ; Camfield, Peter ; Geller, Eric ; Kanner, Andres M ; Keller, Seth ; Kerr, Michael ; Kossoff, Eric H. ; Lau, Heather ; Kothare, Sanjeev ; Singh, Baldev K. ; Wirrell, Elaine. / Delivery of epilepsy care to adults with intellectual and developmental disabilities. In: Neurology. 2015 ; Vol. 85, No. 17. pp. 1512-1521.
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