Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat: II. Regional metabolite levels

Frank A. Welsh, Myron D. Ginsberg, Wendy Rieder, William W. Budd

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

Glucose was infused intravenously into cats prior to cerebral ischemia. Brain concentrations of glucose, measured in 7 regions, were elevated 2.5-fold compared to those of non-infused animals. Ischemia of 15 or 30 minutes duration caused a greater accumulation of lactic acid in the brain of glucose-infused animals. Post-ischemic restitution of cerebral ATP, phosphocreatine, and lactate during 90 minutes of recirculation was severely impaired in the brain of animals pretreated with glucose compared to untreated animals. Thus, excess lactic acidosis may be a major factor interfering with metabolic restitution following cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalStroke
Volume11
Issue number4
DOIs
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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