Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels

F. A. Welsh, Myron Ginsberg, W. Rieder, W. W. Budd

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Glucose was infused intravenously into cats prior to cerebral ischemia. Brain concentrations of glucose, measured in 7 regions, were elevated 2.5-fold compared to those of non-infused animals. Ischemia of 15 or 30 minutes duration caused a greater accumulation of lactic acid in the brain of glucose-infused animals. Post-ischemic restitution of cerebral ATP, phosphocreatine, and lactate during 90 minutes of recirculation was severely impaired in the brain of animals pretreated with glucose compared to untreated animals. Thus, excess lactic acidosis may be a major factor interfering with metabolic restitution following cerebral ischemia.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalStroke
Volume11
Issue number4
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Brain Ischemia
Cats
Glucose
Lactic Acid
Brain
Lactic Acidosis
Phosphocreatine
Ischemia
Adenosine Triphosphate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels. / Welsh, F. A.; Ginsberg, Myron; Rieder, W.; Budd, W. W.

In: Stroke, Vol. 11, No. 4, 01.01.1980, p. 355-362.

Research output: Contribution to journalArticle

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