Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression

The Department of Veterans Affairs Cooperative Study Group

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial ofearly versus late therapy with zidovudine. Patients with a response of >2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52% vs. 27%), development ofAIDS (33% vs. 17%), or death (18% vs. 9%) (P ≤.02), irrespective oftime of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level ofPrmicroglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be ofvalue in the evaluation of a patient's immune status.

Original languageEnglish (US)
Pages (from-to)893-897
Number of pages5
JournalJournal of Infectious Diseases
Volume169
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Delayed Hypersensitivity
Virus Diseases
Skin Tests
Disease Progression
HIV
CD4 Lymphocyte Count
Zidovudine
Antigens
Multivariate Analysis

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression. / The Department of Veterans Affairs Cooperative Study Group.

In: Journal of Infectious Diseases, Vol. 169, No. 4, 1994, p. 893-897.

Research output: Contribution to journalArticle

The Department of Veterans Affairs Cooperative Study Group. / Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression. In: Journal of Infectious Diseases. 1994 ; Vol. 169, No. 4. pp. 893-897.
@article{04c69d3ff8cb421ba349e4ccbff2588d,
title = "Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression",
abstract = "Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial ofearly versus late therapy with zidovudine. Patients with a response of >2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52{\%} vs. 27{\%}), development ofAIDS (33{\%} vs. 17{\%}), or death (18{\%} vs. 9{\%}) (P ≤.02), irrespective oftime of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level ofPrmicroglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be ofvalue in the evaluation of a patient's immune status.",
author = "{The Department of Veterans Affairs Cooperative Study Group} and Gordin, {Fred M.} and Hartigan, {Pamela M.} and Klimas, {Nancy G.} and Pazner, {Susan B Zolla} and Simberkoff, {Michael S.} and Hamilton, {John D.} and Houston, {V. A.} and M. Griffin and K. Harper and Lahart, {C. J.} and D. Musher and A. Peacock and R. Rossen and J. Thomas and J. Wilson and Wray, {N. P.} and V. Allsup and C. Austin and E. Crawford and R. Endow and S. Finegold and J. Fleischman and George, {W. L.} and O′brien, {W. A.} and M. Oliver and D. Reeves and C. Silbar and Gordon Dickinson and R. Greenman and J. Meager and J. Mix and R. Mendez and G. Paperwalla and M. Smith and E. Bailey and Diamond, {G. R.} and W. Ei-Sadr and V. Gianakakos and N. Haren and J. O′leary and A. Cotleur and G. Gilliland and R. Jalbert and Jensen, {P. C.} and M. Marovich and Ziegler, {J. L.} and D. Bille and C. Ebersole and E. Greenberg and Hawkes, {C. A.}",
year = "1994",
doi = "10.1093/infdis/169.4.893",
language = "English (US)",
volume = "169",
pages = "893--897",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression

AU - The Department of Veterans Affairs Cooperative Study Group

AU - Gordin, Fred M.

AU - Hartigan, Pamela M.

AU - Klimas, Nancy G.

AU - Pazner, Susan B Zolla

AU - Simberkoff, Michael S.

AU - Hamilton, John D.

AU - Houston, V. A.

AU - Griffin, M.

AU - Harper, K.

AU - Lahart, C. J.

AU - Musher, D.

AU - Peacock, A.

AU - Rossen, R.

AU - Thomas, J.

AU - Wilson, J.

AU - Wray, N. P.

AU - Allsup, V.

AU - Austin, C.

AU - Crawford, E.

AU - Endow, R.

AU - Finegold, S.

AU - Fleischman, J.

AU - George, W. L.

AU - O′brien, W. A.

AU - Oliver, M.

AU - Reeves, D.

AU - Silbar, C.

AU - Dickinson, Gordon

AU - Greenman, R.

AU - Meager, J.

AU - Mix, J.

AU - Mendez, R.

AU - Paperwalla, G.

AU - Smith, M.

AU - Bailey, E.

AU - Diamond, G. R.

AU - Ei-Sadr, W.

AU - Gianakakos, V.

AU - Haren, N.

AU - O′leary, J.

AU - Cotleur, A.

AU - Gilliland, G.

AU - Jalbert, R.

AU - Jensen, P. C.

AU - Marovich, M.

AU - Ziegler, J. L.

AU - Bille, D.

AU - Ebersole, C.

AU - Greenberg, E.

AU - Hawkes, C. A.

PY - 1994

Y1 - 1994

N2 - Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial ofearly versus late therapy with zidovudine. Patients with a response of >2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52% vs. 27%), development ofAIDS (33% vs. 17%), or death (18% vs. 9%) (P ≤.02), irrespective oftime of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level ofPrmicroglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be ofvalue in the evaluation of a patient's immune status.

AB - Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial ofearly versus late therapy with zidovudine. Patients with a response of >2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52% vs. 27%), development ofAIDS (33% vs. 17%), or death (18% vs. 9%) (P ≤.02), irrespective oftime of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level ofPrmicroglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be ofvalue in the evaluation of a patient's immune status.

UR - http://www.scopus.com/inward/record.url?scp=0028344909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028344909&partnerID=8YFLogxK

U2 - 10.1093/infdis/169.4.893

DO - 10.1093/infdis/169.4.893

M3 - Article

C2 - 7907646

AN - SCOPUS:0028344909

VL - 169

SP - 893

EP - 897

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -