Abstract
Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects.
Original language | English (US) |
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Pages (from-to) | 243-246 |
Number of pages | 4 |
Journal | Brain research |
Volume | 998 |
Issue number | 2 |
DOIs | |
State | Published - Feb 20 2004 |
Keywords
- Edema
- Hemodilution
- Neuroprotection
- Stroke
ASJC Scopus subject areas
- Neuroscience(all)