Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats

Ludmila Belayev, Larissa Khoutorova, Andrey Belayev, Yangbo Zhang, Weizhao Zhao, Raul Busto, Myron D. Ginsberg

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalBrain Research
Volume998
Issue number2
DOIs
StatePublished - Feb 20 2004

Keywords

  • Edema
  • Hemodilution
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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