Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats

Ludmila Belayev; Larissa Khoutorova; Andrey Belayev; Yangbo Zhang; Weizhao Zhao; Raul Busto; Myron D. Ginsberg

doi:10.1016/j.brainres.2003.11.015

Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats

Ludmila Belayev, Larissa Khoutorova, Andrey Belayev, Yangbo Zhang, Weizhao Zhao, Raul Busto, Myron D. Ginsberg

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects.

Original language	English (US)
Pages (from-to)	243-246
Number of pages	4
Journal	Brain research
Volume	998
Issue number	2
DOIs	https://doi.org/10.1016/j.brainres.2003.11.015
State	Published - Feb 20 2004

Keywords

Edema
Hemodilution
Neuroprotection
Stroke

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.brainres.2003.11.015

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Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats. / Belayev, Ludmila; Khoutorova, Larissa; Belayev, Andrey; Zhang, Yangbo; Zhao, Weizhao; Busto, Raul; Ginsberg, Myron D.

In: Brain research, Vol. 998, No. 2, 20.02.2004, p. 243-246.

Research output: Contribution to journal › Article › peer-review

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abstract = "Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects.",

keywords = "Edema, Hemodilution, Neuroprotection, Stroke",

author = "Ludmila Belayev and Larissa Khoutorova and Andrey Belayev and Yangbo Zhang and Weizhao Zhao and Raul Busto and Ginsberg, {Myron D.}",

note = "Funding Information: Supported by NIH Grants NS05820 and NS40406 (MDG). The authors thank G. Fernandez and J.Y. Loor for their expert technical assistance.",

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AU - Belayev, Ludmila

AU - Khoutorova, Larissa

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AU - Zhang, Yangbo

AU - Zhao, Weizhao

AU - Busto, Raul

AU - Ginsberg, Myron D.

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N2 - Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects.

AB - Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects.

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KW - Hemodilution

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Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats

Abstract

Keywords

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