Abstract
Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].
| Original language | English (US) |
|---|---|
| Pages (from-to) | e60-e64 |
| Journal | Journal of pediatric ophthalmology and strabismus |
| Volume | 56 |
| DOIs | |
| State | Published - Oct 17 2019 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Ophthalmology
Cite this
Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome. / Patel, Nimesh A.; Han, Elaine; Yannuzzi, Nicolas A.; Fan, Kenneth C.; Negron, Catherin I.; Prakhunhungsit, Supalert; Mendoza-Santiesteban, Carlos E.; Berrocal, Audina M.
In: Journal of pediatric ophthalmology and strabismus, Vol. 56, 17.10.2019, p. e60-e64.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome
AU - Patel, Nimesh A.
AU - Han, Elaine
AU - Yannuzzi, Nicolas A.
AU - Fan, Kenneth C.
AU - Negron, Catherin I.
AU - Prakhunhungsit, Supalert
AU - Mendoza-Santiesteban, Carlos E.
AU - Berrocal, Audina M.
PY - 2019/10/17
Y1 - 2019/10/17
N2 - Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].
AB - Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].
UR - http://www.scopus.com/inward/record.url?scp=85073544686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073544686&partnerID=8YFLogxK
U2 - 10.3928/01913913-20190813-01
DO - 10.3928/01913913-20190813-01
M3 - Article
C2 - 31622479
AN - SCOPUS:85073544686
VL - 56
SP - e60-e64
JO - Journal of Pediatric Ophthalmology and Strabismus
JF - Journal of Pediatric Ophthalmology and Strabismus
SN - 0191-3913
ER -