Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome

Nimesh A. Patel; Elaine Han; Nicolas A. Yannuzzi; Kenneth C. Fan; Catherin I. Negron; Supalert Prakhunhungsit; Carlos E. Mendoza-Santiesteban; Audina M. Berrocal

doi:10.3928/01913913-20190813-01

Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome

Nimesh A. Patel, Elaine Han, Nicolas A. Yannuzzi, Kenneth C. Fan, Catherin I. Negron, Supalert Prakhunhungsit, Carlos E. Mendoza-Santiesteban, Audina M. Berrocal

Ophthalmology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].

Original language	English (US)
Pages (from-to)	e60-e64
Journal	Journal of pediatric ophthalmology and strabismus
Volume	56
DOIs	https://doi.org/10.3928/01913913-20190813-01
State	Published - Oct 17 2019

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Ophthalmology

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Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome. / Patel, Nimesh A.; Han, Elaine; Yannuzzi, Nicolas A.; Fan, Kenneth C.; Negron, Catherin I.; Prakhunhungsit, Supalert; Mendoza-Santiesteban, Carlos E.; Berrocal, Audina M.

In: Journal of pediatric ophthalmology and strabismus, Vol. 56, 17.10.2019, p. e60-e64.

Research output: Contribution to journal › Article › peer-review

Patel, Nimesh A. ; Han, Elaine ; Yannuzzi, Nicolas A. ; Fan, Kenneth C. ; Negron, Catherin I. ; Prakhunhungsit, Supalert ; Mendoza-Santiesteban, Carlos E. ; Berrocal, Audina M. / Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome. In: Journal of pediatric ophthalmology and strabismus. 2019 ; Vol. 56. pp. e60-e64.

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abstract = "Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].",

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AU - Negron, Catherin I.

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AB - Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].

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Delayed Onset of Retinopathy of Prematurity Associated With Mitochondrial Dysfunction and Pearson Syndrome

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