Delayed hippocampal damage in humans following cardiorespiratory arrest.

Carol Petito, E. Feldmann, W. A. Pulsinelli, F. Plum

Research output: Contribution to journalArticle

555 Citations (Scopus)

Abstract

Transient ischemia in animals produces delayed cell death in vulnerable hippocampal neurons. To see if this occurs in humans, we reexamined brain slides from all patients with anoxic-ischemic encephalopathy and a well-documented cardiorespiratory arrest. Eight patients dying 18 hours or less after cardiac arrest had minimal damage in hippocampus and moderate damage in cerebral cortex and putamen. Six patients living 24 hours or more had severe damage in all four regions. The increase in damage with time postarrest was significant only in the hippocampus. Delayed hippocampal injury now documented in humans provides a target for possible therapy that can be initiated after cardiopulmonary resuscitation.

Original languageEnglish
Pages (from-to)1281-1286
Number of pages6
JournalNeurology
Volume37
Issue number8
StatePublished - Aug 1 1987
Externally publishedYes

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Hippocampus
Brain Hypoxia-Ischemia
Putamen
Cardiopulmonary Resuscitation
Heart Arrest
Cerebral Cortex
Cell Death
Ischemia
Neurons
Wounds and Injuries
Brain
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Petito, C., Feldmann, E., Pulsinelli, W. A., & Plum, F. (1987). Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology, 37(8), 1281-1286.

Delayed hippocampal damage in humans following cardiorespiratory arrest. / Petito, Carol; Feldmann, E.; Pulsinelli, W. A.; Plum, F.

In: Neurology, Vol. 37, No. 8, 01.08.1987, p. 1281-1286.

Research output: Contribution to journalArticle

Petito, C, Feldmann, E, Pulsinelli, WA & Plum, F 1987, 'Delayed hippocampal damage in humans following cardiorespiratory arrest.', Neurology, vol. 37, no. 8, pp. 1281-1286.
Petito C, Feldmann E, Pulsinelli WA, Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology. 1987 Aug 1;37(8):1281-1286.
Petito, Carol ; Feldmann, E. ; Pulsinelli, W. A. ; Plum, F. / Delayed hippocampal damage in humans following cardiorespiratory arrest. In: Neurology. 1987 ; Vol. 37, No. 8. pp. 1281-1286.
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