Delayed hippocampal damage in humans following cardiorespiratory arrest

Carol K. Petito, Edward Feldmann, William A. Pulsinelli, Fred Plum

Research output: Contribution to journalArticlepeer-review

582 Scopus citations


Transient ischemia in animals produces delayed cell death in vulnerable hippocampal neurons. To see if this occurs in humans, we reexamined brain slides from all patients with anoxic-ischemic encephalopathy and a well-documented cardiorespiratory arrest. Eight patients dying 18 hours or less after cardiac arrest had minimal damage in hippocampus and moderate damage in cerebral cortex and putamen. Six patients living 24 hours or more had severe damage in all four regions. The increase in damage with time postarrest was significant only in the hippocampus. Delayed hippocampal injury now documented in humans provides a target for possible therapy that can be initiated after cardiopulmonary resuscitation.

Original languageEnglish (US)
Pages (from-to)1281-1286
Number of pages6
Issue number8
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Clinical Neurology


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