Delayed gastric emptying after pancreaticoduodenectomy

Mena M. Hanna, Rahul Gadde, Casey J. Allen, Jonathan P. Meizoso, Danny Sleeman, Alan Livingstone, Nipun Merchant, Danny Yakoub

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background Delayed gastric emptying (DGE) remains an unsolved complication after pancreaticoduodenectomy (PD) with conflicting reports of its cause. We aimed to compare the effect of surgical techniques involving the stomach in PD in lowering the risk of postoperative DGE. Methods Online search and review of key bibliographies in PubMed, Medline, Embase, Scopus, Cochrane, and Google Scholar was performed. Studies comparing PD surgical techniques were identified. Primary outcome was postoperative DGE. Methodological quality was assessed using Strengthening the Reporting of Observational Studies in Epidemiology and Consolidated Standards of Reporting Trials. Calculated pooled relative risk and odds ratios (ORs) with the corresponding 95% confidence interval (CI) were used in the meta-analyses. Results Overall, 376 studies were reviewed, of which 22 studies were selected including a total of 5172 patients. The incidence of DGE was lower in antecolic compared with retrocolic gastrojejunostomy (risk ratio [RR], 0.260; CI, 0.157-0.431; P <0.001; n = 1067 patients) and in subtotal stomach preserving PD compared with pylorus preserving PD (RR, 0.527; CI, 0.363-0.763; P <0.001; n = 663 patients). There was no significant difference between classic PD versus pylorus preserving PD (OR, 0.64; CI, 0.40-1.00; P = 0.05; n = 1209 patients), pancreaticogastrostomy versus pancreaticojejunostomy (RR, 1.02; CI, 0.62-1.68; P = 0.94; n = 961 patients), Roux-en-Y versus Billroth II gastrojejunostomy (RR, 0.946; CI, 0.788-1.136; P = 0.5513; n = 470 patients), or minimally invasive PD versus open PD (OR, 0.99; CI, 0.62-1.56; P = 0.96; n = 802). Conclusions In PD, surgical techniques using antecolic reconstruction route and subtotal stomach preserving PD seem to be associated with a lower risk of DGE. Further randomized controlled trials are necessary to evaluate these results taking other causes into consideration.

Original languageEnglish (US)
Pages (from-to)380-388
Number of pages9
JournalJournal of Surgical Research
Volume202
Issue number2
DOIs
StatePublished - May 15 2016

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Keywords

  • Antecolic
  • Delayed gastric emptying
  • Gastrojejunostomy
  • Minimally invasive pancreaticoduodenectomy
  • Pancreaticogasterostomy
  • Pancreaticojejunostomy
  • Pylorus preserving pancreaticoduodenectomy
  • Retrocolic
  • Roux-en-Y
  • Subtotal stomach preserving pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery

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