Sixteen consecutively admitted patients with malignant melanoma were skin tested with autologous lumor extract (ATE), a varietyof cutaneous antigens, and when available, autologous normal skin extracts (ASE). A protein concentralion of 1 mg/ml was used as the criticalantigenic challenge for both ATE and ASE testing. Anergy was not encountered in any of this group. Positive delayed sensitivity reactions toATE were elicited in 11 patients, 9 of whom were also tested with ASE.Six of the nine (67%) reacted to the ASE as well. The implications of concomitant ATE and ASE reactivity are discussed. No correlation was notedbetween ASE reactivity and the presence of vitiligo in these patients. Nocorrelation was noted between ATE skin-test reactivity and sex, age, length of history prior to hospitalization, primary disease site, presence ofregional node involvement, distant metastases, vitiligo, or duration ofremission, even in the 3 patients reacting to ATE and not to ASE. Naturallyoccurring cutaneous reactivity to extracts of autologous melanoma cellsdoes not currently appear to represent an effective immunological barrierto tumor progression, though future studies may suggest significant clinicalapplication of this phenomenon.—J Nat Cancer Inst 48: 17-24, 1972.
ASJC Scopus subject areas
- Cancer Research