Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)

L. M. Demeter; R. W. Shafer; P. M. Meehan; J. Holden-Wiltse; M. A. Fischl; W. W. Freimuth; M. F. Para; R. C. Reichman

doi:10.1128/AAC.44.3.794-797.2000

Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)

L. M. Demeter, R. W. Shafer, P. M. Meehan, J. Holden-Wiltse, M. A. Fischl, W. W. Freimuth, M. F. Para, R. C. Reichman

Medicine

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The development of human immunodeficiency virus type 1 resistance to delavirdine (DLV) was studied in subjects receiving DLV monotherapy. Phenotypic resistance developed in 28 of 30 subjects within 8 weeks. K103N and Y181C, which confer nonnucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance, were the predominant reverse transcriptase mutations. P236L, which confers DLV resistance but hypersensitivity to other NNRTIs, developed in <10% of isolates.

Original language	English (US)
Pages (from-to)	794-797
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	44
Issue number	3
DOIs	https://doi.org/10.1128/AAC.44.3.794-797.2000
State	Published - Mar 2000

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.44.3.794-797.2000

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Demeter, L. M., Shafer, R. W., Meehan, P. M., Holden-Wiltse, J., Fischl, M. A., Freimuth, W. W., Para, M. F., & Reichman, R. C. (2000). Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260). Antimicrobial agents and chemotherapy, 44(3), 794-797. https://doi.org/10.1128/AAC.44.3.794-797.2000

Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260). / Demeter, L. M.; Shafer, R. W.; Meehan, P. M.; Holden-Wiltse, J.; Fischl, M. A.; Freimuth, W. W.; Para, M. F.; Reichman, R. C.

In: Antimicrobial agents and chemotherapy, Vol. 44, No. 3, 03.2000, p. 794-797.

Research output: Contribution to journal › Article › peer-review

Demeter, LM, Shafer, RW, Meehan, PM, Holden-Wiltse, J, Fischl, MA, Freimuth, WW, Para, MF & Reichman, RC 2000, 'Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)', Antimicrobial agents and chemotherapy, vol. 44, no. 3, pp. 794-797. https://doi.org/10.1128/AAC.44.3.794-797.2000

Demeter LM, Shafer RW, Meehan PM, Holden-Wiltse J, Fischl MA, Freimuth WW et al. Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260). Antimicrobial agents and chemotherapy. 2000 Mar;44(3):794-797. https://doi.org/10.1128/AAC.44.3.794-797.2000

Demeter, L. M. ; Shafer, R. W. ; Meehan, P. M. ; Holden-Wiltse, J. ; Fischl, M. A. ; Freimuth, W. W. ; Para, M. F. ; Reichman, R. C. / Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260). In: Antimicrobial agents and chemotherapy. 2000 ; Vol. 44, No. 3. pp. 794-797.

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abstract = "The development of human immunodeficiency virus type 1 resistance to delavirdine (DLV) was studied in subjects receiving DLV monotherapy. Phenotypic resistance developed in 28 of 30 subjects within 8 weeks. K103N and Y181C, which confer nonnucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance, were the predominant reverse transcriptase mutations. P236L, which confers DLV resistance but hypersensitivity to other NNRTIs, developed in <10% of isolates.",

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