Deiodinases: Implications of the local control of thyroid hormone action

Antonio C. Bianco, Brian W. Kim

Research output: Contribution to journalReview article

484 Scopus citations

Abstract

The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.

Original languageEnglish (US)
Pages (from-to)2571-2579
Number of pages9
JournalJournal of Clinical Investigation
Volume116
Issue number10
DOIs
StatePublished - Oct 2 2006

ASJC Scopus subject areas

  • Medicine(all)

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