Deimination in ocular tissues: Present and future

Di Ding, Mabel Enriquez-Algeciras, Vera L. Bonilha, Sanjoy K. Bhattacharya

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Deimination refers to the posttranslational conversion of protein-bound arginines into protein-bound citrullines, catalyzed by peptidyl arginine deiminase (PAD) enzymes (Vossenaar et al. 2003). Lack of a carrier tRNA for citrulline has established deimination as a posttranslational modification. Deimination and citrullination are interchangeably used for conversion of arginine into citrulline. To distinguish free arginine citrullination from protein-bound citrullination, we prefer referring to the latter as deimination (Bhattacharya 2009). Throughout this chapter we use deimination to refer to the conversion of protein-bound arginine modification into citrulline.

Original languageEnglish (US)
Title of host publicationProtein Deimination in Human Health and Disease
PublisherSpringer New York
Pages295-303
Number of pages9
ISBN (Electronic)9781461483175
ISBN (Print)1461483166, 9781461483168
DOIs
StatePublished - Jan 1 2014

Keywords

  • Age-related macular degeneration
  • Aging
  • Glaucoma
  • Ocular deimination
  • Retina

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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