Degradation of RNA in bacteria: Comparison of mRNA and stable RNA

Murray P Deutscher

Research output: Contribution to journalArticle

272 Citations (Scopus)

Abstract

Degradation of RNA plays a central role in RNA metabolism. In recent years, our knowledge of the mechanisms of RNA degradation has increased considerably with discovery of the participating RNases and analysis of mutants affected in the various degradative pathways. Among these processes, mRNA decay and stable RNA degradation generally have been considered distinct, and also separate from RNA maturation. In this review, each of these processes is described, as it is currently understood in bacteria. The picture that emerges is that decay of mRNA and degradation of stable RNA share many common features, and that their initial steps also overlap with those of RNA maturation. Thus, bacterial cells do not contain dedicated machinery for degradation of different classes of RNA or for different processes. Rather, only the specificity of the RNase and the accessibility of the substrate determine whether or not a particular RNA will be acted upon.

Original languageEnglish
Pages (from-to)659-666
Number of pages8
JournalNucleic Acids Research
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2006

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RNA Stability
RNA
Bacteria
Messenger RNA
Ribonucleases

ASJC Scopus subject areas

  • Genetics

Cite this

Degradation of RNA in bacteria : Comparison of mRNA and stable RNA. / Deutscher, Murray P.

In: Nucleic Acids Research, Vol. 34, No. 2, 01.02.2006, p. 659-666.

Research output: Contribution to journalArticle

Deutscher, Murray P. / Degradation of RNA in bacteria : Comparison of mRNA and stable RNA. In: Nucleic Acids Research. 2006 ; Vol. 34, No. 2. pp. 659-666.
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