Degenerative lesions in rat sciatic nerves local injections of methylprednisolone in sterile aqueous suspension

Kathleen M. Wood, Jaime Arguelles, Michael D. Norenberg

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Rat sciatic nerves were exposed to injections o f methylprednisolone acetate suspension (MPAS), the suspension vehicle without methylprednisolone, a local anesthetic (chloroprocaine 1%), and repealed needle punctures. The nerves were taken fo r histological study and compared with untreated controls. Nerves treated with the methylprednisolone suspension and its sterile vehicle showed similar incidence and severity o f patchy degenerative changes, including demyelination, axonal disorganization, and endoneurial collagen formation. These findings suggest that repealed injections o f MPAS near a peripheral nerve may cause nerve damage.

Original languageEnglish (US)
Pages (from-to)13-15
Number of pages3
JournalRegional Anesthesia
Volume15
Issue number5
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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