Rat sciatic nerves were exposed to injections o f methylprednisolone acetate suspension (MPAS), the suspension vehicle without methylprednisolone, a local anesthetic (chloroprocaine 1%), and repealed needle punctures. The nerves were taken fo r histological study and compared with untreated controls. Nerves treated with the methylprednisolone suspension and its sterile vehicle showed similar incidence and severity o f patchy degenerative changes, including demyelination, axonal disorganization, and endoneurial collagen formation. These findings suggest that repealed injections o f MPAS near a peripheral nerve may cause nerve damage.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jan 1 1990|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine