Abstract
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female. Acute mucositis could impair nutrition, quality of life, and treatment intensity especially given her age. We compared 3 techniques that are appropriate for this target: step-and-shoot IMRT, matched electron fields (MEF), and electron conformal therapy (BolusECT™). We selected and treated her with BolusECT™ because of better sparing of larynx, pharynx, oral cavity and lips, and shortest treatment time. This is a reasonable option for treating ipsilateral head and neck target volumes at centers where only these 3 techniques are available.
| Original language | English (US) |
|---|---|
| Journal | Medical Dosimetry |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Comparative dosimetry
- Electron beam
- Merkel cell carcinoma
- Quality of life
- Variable thickness compensator
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Oncology
- Radiology Nuclear Medicine and imaging
Cite this
Definitive radiotherapy for a head and neck Merkel cell carcinoma and comprehensive nodal volumes : A case for using a computer-designed variable-thickness compensator to reduce risk and severity of mucositis. / Ahamad, Anesa; Weed, Donald; Pruett, Darel D.; Saulpaugh, Daniel; Neeranjun, Womah; Fernandez, Eduardo.
In: Medical Dosimetry, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Definitive radiotherapy for a head and neck Merkel cell carcinoma and comprehensive nodal volumes
T2 - A case for using a computer-designed variable-thickness compensator to reduce risk and severity of mucositis
AU - Ahamad, Anesa
AU - Weed, Donald
AU - Pruett, Darel D.
AU - Saulpaugh, Daniel
AU - Neeranjun, Womah
AU - Fernandez, Eduardo
PY - 2017
Y1 - 2017
N2 - When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female. Acute mucositis could impair nutrition, quality of life, and treatment intensity especially given her age. We compared 3 techniques that are appropriate for this target: step-and-shoot IMRT, matched electron fields (MEF), and electron conformal therapy (BolusECT™). We selected and treated her with BolusECT™ because of better sparing of larynx, pharynx, oral cavity and lips, and shortest treatment time. This is a reasonable option for treating ipsilateral head and neck target volumes at centers where only these 3 techniques are available.
AB - When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female. Acute mucositis could impair nutrition, quality of life, and treatment intensity especially given her age. We compared 3 techniques that are appropriate for this target: step-and-shoot IMRT, matched electron fields (MEF), and electron conformal therapy (BolusECT™). We selected and treated her with BolusECT™ because of better sparing of larynx, pharynx, oral cavity and lips, and shortest treatment time. This is a reasonable option for treating ipsilateral head and neck target volumes at centers where only these 3 techniques are available.
KW - Comparative dosimetry
KW - Electron beam
KW - Merkel cell carcinoma
KW - Quality of life
KW - Variable thickness compensator
UR - http://www.scopus.com/inward/record.url?scp=85030857865&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030857865&partnerID=8YFLogxK
U2 - 10.1016/j.meddos.2017.08.006
DO - 10.1016/j.meddos.2017.08.006
M3 - Article
C2 - 29031904
AN - SCOPUS:85030857865
JO - Medical Dosimetry
JF - Medical Dosimetry
SN - 0958-3947
ER -