Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

R. C. Bone, R. A. Balk, F. B. Cerra, R. P. Dellinger, A. M. Fein, W. A. Knaus, Roland Schein, W. J. Sibbald

Research output: Contribution to journalArticle

6303 Citations (Scopus)

Abstract

An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae. New definitions were offered for some terms, while others were discarded. Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized. Definitions for severe sepsis, septic shock, hypotension, and multiple organ dysfunction syndrome were also offered. The use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality. Appropriate methods and applications for the use and testing of new therapies were recommended. The use of these terms and techniques should assist clinicians and researchers who deal with sepsis and its sequelae.

Original languageEnglish
Pages (from-to)1644-1655
Number of pages12
JournalChest
Volume101
Issue number6
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Investigational Therapies
Sepsis
Guidelines
Systemic Inflammatory Response Syndrome
Multiple Organ Failure
Septic Shock
Hypotension
Research Design
Research Personnel
Mortality
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bone, R. C., Balk, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., ... Sibbald, W. J. (1992). Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest, 101(6), 1644-1655.

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. / Bone, R. C.; Balk, R. A.; Cerra, F. B.; Dellinger, R. P.; Fein, A. M.; Knaus, W. A.; Schein, Roland; Sibbald, W. J.

In: Chest, Vol. 101, No. 6, 01.01.1992, p. 1644-1655.

Research output: Contribution to journalArticle

Bone, RC, Balk, RA, Cerra, FB, Dellinger, RP, Fein, AM, Knaus, WA, Schein, R & Sibbald, WJ 1992, 'Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis', Chest, vol. 101, no. 6, pp. 1644-1655.
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992 Jan 1;101(6):1644-1655.
Bone, R. C. ; Balk, R. A. ; Cerra, F. B. ; Dellinger, R. P. ; Fein, A. M. ; Knaus, W. A. ; Schein, Roland ; Sibbald, W. J. / Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. In: Chest. 1992 ; Vol. 101, No. 6. pp. 1644-1655.
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