Defining the System: Contributors to Exercise Limitations in Heart Failure

Shane A. Phillips, Karen Vuckovic, Lawrence P. Cahalin, Tracy Baynard

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


One of the primary hallmarks of patients diagnosed with heart failure (HF) is a reduced tolerance to exercise and compromised functional capacity. This limitation stems from poor pumping capacity but also major changes in functioning of the vasculature, skeletal muscle, and respiratory systems. Advances in the understanding of the central and peripheral mechanisms of exercise intolerance during HF are critical for the future design of therapeutic modalities devised to improve outcomes. The interrelatedness between systems cannot be discounted. This review summarizes the current literature related to the pathophysiology of HF contributing to poor exercise tolerance, and potential mechanisms involved.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalHeart failure clinics
Issue number1
StatePublished - Jan 1 2015


  • Cardiopulmonary
  • Exercise
  • Heart failure
  • Intolerance
  • Skeletal muscle
  • Vascular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Defining the System: Contributors to Exercise Limitations in Heart Failure'. Together they form a unique fingerprint.

Cite this