Abstract
Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in adults, with important differences in pathophysiology and clinical course. Therefore, the efficacy of disease-modifying therapies may be different in the two populations. Understanding the developmental and regulatory pathways for type 1 diabetes-modifying therapies in children will enable industry, academia, funders, advocacy groups, and regulators to translate new science to clinical care. This consensus report characterizes the fundamental differences in type 1 diabetes between children and adults and proposes a thoughtful approach to better understand the development and regulatory pathways for type 1 diabetes therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1975-1985 |
| Number of pages | 11 |
| Journal | Diabetes Care |
| Volume | 38 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2015 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialized Nursing
Cite this
Defining Pathways forDevelopment of Disease-Modifying Therapies in Children With Type 1 Diabetes : A Consensus Report. / Wherrett, Diane K.; Chiang, Jane L.; Delamater, Alan M; Dimeglio, Linda A.; Gitelman, Stephen E.; Gottlieb, Peter A.; Herold, Kevan C.; Lovell, Daniel J.; Orchard, Trevor J.; Ryan, Christopher M.; Schatz, Desmond A.; Wendler, David S.; Greenbaum, Carla J.
In: Diabetes Care, Vol. 38, No. 10, 01.10.2015, p. 1975-1985.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Defining Pathways forDevelopment of Disease-Modifying Therapies in Children With Type 1 Diabetes
T2 - A Consensus Report
AU - Wherrett, Diane K.
AU - Chiang, Jane L.
AU - Delamater, Alan M
AU - Dimeglio, Linda A.
AU - Gitelman, Stephen E.
AU - Gottlieb, Peter A.
AU - Herold, Kevan C.
AU - Lovell, Daniel J.
AU - Orchard, Trevor J.
AU - Ryan, Christopher M.
AU - Schatz, Desmond A.
AU - Wendler, David S.
AU - Greenbaum, Carla J.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in adults, with important differences in pathophysiology and clinical course. Therefore, the efficacy of disease-modifying therapies may be different in the two populations. Understanding the developmental and regulatory pathways for type 1 diabetes-modifying therapies in children will enable industry, academia, funders, advocacy groups, and regulators to translate new science to clinical care. This consensus report characterizes the fundamental differences in type 1 diabetes between children and adults and proposes a thoughtful approach to better understand the development and regulatory pathways for type 1 diabetes therapies.
AB - Emerging data suggest that type 1 diabetes is a more aggressive disease in children than in adults, with important differences in pathophysiology and clinical course. Therefore, the efficacy of disease-modifying therapies may be different in the two populations. Understanding the developmental and regulatory pathways for type 1 diabetes-modifying therapies in children will enable industry, academia, funders, advocacy groups, and regulators to translate new science to clinical care. This consensus report characterizes the fundamental differences in type 1 diabetes between children and adults and proposes a thoughtful approach to better understand the development and regulatory pathways for type 1 diabetes therapies.
UR - http://www.scopus.com/inward/record.url?scp=84962406567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962406567&partnerID=8YFLogxK
U2 - 10.2337/dc15-1429
DO - 10.2337/dc15-1429
M3 - Article
VL - 38
SP - 1975
EP - 1985
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 10
ER -