Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma

Elisa Ramirez, Rajesh R. Singh, Kranthi Kunkalla, Yadong Liu, Changju Qu, Christine Cain, Asha S. Multani, Patrick A. Lennon, Jared Jackacky, Michael Ho, Sity Dawud, Jun Gu, Su Yang, Peter C. Hu, Francisco Vega

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Hedgehog (Hh) signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL). Genetic abnormalities that explain activation of Hh signaling in DLBCL are unknown. We investigate the presence of amplifications of Hh genes that might result in activation of this pathway in DLBCL. Our data showed few extra copies of GLI1 and SMO due to chromosomal aneuploidies in a subset of DLBCL cell lines. We also showed that pharmacologic inhibition of PI3K/AKT and NF-κB pathways resulted in decreased expression of GLI1 and Hh ligands. In conclusion, our data support the hypothesis that aberrant activation of Hh signaling in DLBCL mainly results from integration of deregulated oncogenic signaling inputs converging into Hh signaling.

Original languageEnglish (US)
Pages (from-to)1267-1273
Number of pages7
JournalLeukemia Research
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Keywords

  • Diffuse large B-cell lymphoma
  • Gene copy number
  • GLI
  • Hedgehog pathway

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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  • Cite this

    Ramirez, E., Singh, R. R., Kunkalla, K., Liu, Y., Qu, C., Cain, C., Multani, A. S., Lennon, P. A., Jackacky, J., Ho, M., Dawud, S., Gu, J., Yang, S., Hu, P. C., & Vega, F. (2012). Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma. Leukemia Research, 36(10), 1267-1273. https://doi.org/10.1016/j.leukres.2012.06.014