DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS?

HughMca Taggart, CharlesH Chesnut, JoelL Ivey, Karen Sisom, DavidJ Baylink, M. B. Huber, B. A. Roos

Research output: Contribution to journalArticle

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Abstract

To test whether mobilisation of immunoreactive calcitonin in response to calcium challenge is reduced in postmenopausal osteoporosis, seventeen postmenopausal osteoporotic women with compression fractures and ten normal agematched women were given intravenous infusions of 3 mg/kg elemental calcium over a 10 min period. Blood samples were obtained 5 min before and at 0, 10, 20, and 60 min after start of infusion for the measurement of serum calcium and plasma immunoreactive calcitonin. Serum calcium increased significantly from baseline in both normal and osteoporotic groups; immunoreactive calcitonin increased significantly in the controls 10 min and 20 min after the start of infusion, but in the women with osteoporosis calcitonin levels did not change significantly at any time. 20 min after the start of infusion the change in immunoreactive calcitonin from baseline was significantly less in osteoporotic women than in the controls. These data are consistent with a decreased immunoreactive calcitonin response to calcium infusion in postmenopausal osteoporotic women, and suggest that calcitonin deficiency may be involved in the development of postmenopausal osteoporosis.

Original languageEnglish
Pages (from-to)475-478
Number of pages4
JournalThe Lancet
Volume319
Issue number8270
DOIs
StatePublished - Feb 27 1982
Externally publishedYes

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Postmenopausal Osteoporosis
Calcitonin
Calcium
Compression Fractures
Serum
Intravenous Infusions
Osteoporosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Taggart, H., Chesnut, C., Ivey, J., Sisom, K., Baylink, D., Huber, M. B., & Roos, B. A. (1982). DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS? The Lancet, 319(8270), 475-478. https://doi.org/10.1016/S0140-6736(82)91451-9

DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS? / Taggart, HughMca; Chesnut, CharlesH; Ivey, JoelL; Sisom, Karen; Baylink, DavidJ; Huber, M. B.; Roos, B. A.

In: The Lancet, Vol. 319, No. 8270, 27.02.1982, p. 475-478.

Research output: Contribution to journalArticle

Taggart, H, Chesnut, C, Ivey, J, Sisom, K, Baylink, D, Huber, MB & Roos, BA 1982, 'DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS?', The Lancet, vol. 319, no. 8270, pp. 475-478. https://doi.org/10.1016/S0140-6736(82)91451-9
Taggart H, Chesnut C, Ivey J, Sisom K, Baylink D, Huber MB et al. DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS? The Lancet. 1982 Feb 27;319(8270):475-478. https://doi.org/10.1016/S0140-6736(82)91451-9
Taggart, HughMca ; Chesnut, CharlesH ; Ivey, JoelL ; Sisom, Karen ; Baylink, DavidJ ; Huber, M. B. ; Roos, B. A. / DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS?. In: The Lancet. 1982 ; Vol. 319, No. 8270. pp. 475-478.
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