Deficient B lymphopoiesis in murine senescence: Potential roles for dysregulation of E2A, Pax-5, and STAT5

Richard L. Riley, Elaine Van Der Put, Anne M. King, Daniela Frasca, Bonnie B. Blomberg

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

B lymphopoiesis in senescent mice is typically diminished and characterized by low pre-B cell numbers. The transcription factors E2A, Pax-5, and STAT5 have been implicated in the differentiation, proliferation, and survival of B cell precursors. In this review, we discuss the impairment of B lymphopoiesis during old age in the context of mechanisms at the molecular level responsible for the handling and turnover of these key transcriptional proteins. Alterations in the expression of E2A, Pax-5, and STAT5 may affect multiple stages of B cell development, contribute to reduced B lymphopoiesis, and preface changes in the "read-out" of the BCR repertoire during murine senescence.

Original languageEnglish (US)
Pages (from-to)330-336
Number of pages7
JournalSeminars in Immunology
Volume17
Issue number5
DOIs
StatePublished - Oct 2005

Keywords

  • Aging
  • B lymphopoiesis
  • Cytokines
  • Transcription factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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