Defective B-lymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome

S. G. Pahwa, T. J. Quilop, M. Lange, M. H. Grieco

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Patients with the acquired immunodeficiency syndrome manifest a wide spectrum of immunologic abnormalities. Polyclonal and antigen-specific differentiation of B lymphocytes into immunoglobulin- and antibody-secreting cells was studied in-vitro in three groups of homosexual volunteers: asymptomatic men; men who were symptomatic but lacked clinical criteria for the acquired immunodeficiency syndrome; and those having the syndrome. Although the responses of all three groups were significantly lower than those of healthy homosexual male controls, those of the asymptomatic group were least affected. Abnormalities in the symptomatic group were equal to or greater than those of patients with the syndrome, but responses of the latter group were the least augmentable by in-vitro manipulations. Severe impairment of B-cell function appeared to favor clinical deterioration. Antibody replenishment might be of value as adjunctive therapy in persons with the acquired immunodeficiency syndrome or as prophylaxis in certain at-risk persons.

Original languageEnglish (US)
Pages (from-to)757-763
Number of pages7
JournalAnnals of internal medicine
Volume101
Issue number6
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine

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