Deep sclerectomy with and without implant: An in-vivo comparative study

Mitsumo Yamamichi, Philippe Sourdille, Hassan Tahi, Valerie Jallet, Franck L. Villain, Francisco Fantes, Jean Marie Parel

Research output: Contribution to journalConference articlepeer-review


Purpose: Establish the effects of pre-Descemetic sclero-keratectomy, a new nonpenetrating Deep-Sclerectomy filtration procedure, with and without crosslinked sodium hyaluronic acid (SKgel) implant in the rabbit animal model. Materials and Methods: Ten adult NZW rabbits had surgery only (group A) and 15 other had surgery and a crosslinked sodium hyaluronate implant inserted under the scleral flap (group B). Weekly intraocular pressure (IOP), outflow facility, and central and peripheral corneal thicknesses were measured in both the operated and the contralateral eye over a period of five months in Group A and six months in Group B. Results: lOP was consistently lower until POD 21 for Group A and POD 161 for Group B, respectively (P < 0.05). Outflow facility was significantly higher than control eyes until POD 14 in Group A and until POD 84 in Group B. Peripheral corneal thickness returned to normal by POD 14 in Group A and POD 28 in Group B. By POD 35, there was no statistical significance between both groups in the mean of peripheral corneal thickness. Conclusion: Pre-Descemetic Sclero-Keratectomy with crosslinked sodium hyaluronate implant is effective in reducing IOP and safe operation in rabbit eyes.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1998
EventProceedings of Ophthalmic Technologies VIII - San Jose, CA, United States
Duration: Jan 24 1998Jan 25 1998


  • Biodegradation
  • Deep Sclerectomy
  • Glaucoma
  • Hyaluronic Acid (HA)
  • Implant
  • Nonpenetrating filtering surgery
  • Sodium Hyaluronate

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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