Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (+)[11C]dihydrotetrabenazine and positron emission tomography

Sid Gilman, Robert A. Koeppe, Kenneth M. Adams, Larry Junck, Karen J. Kluin, Doug Johnson-Greene, Susan Martorello, Mary Heumann, Rajesh Bandekar

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

We used (+)[11C]dihydrotetrabenazine, a new ligand for the type 2 vesicular monoamine transporter, with positron emission tomography to study striatal monoaminergic presynaptic terminals in 7 male severe chronic alcoholic subjects without Wernicke-Korsakoff disease compared with 7 male normal controls of similar ages. We found reduced specific binding in the caudate nucleus and putamen in the alcoholic group, and the difference reached significance in the putamen. Specific binding was not decreased in the thalamus, which was examined as a reference structure. We also detected deficits in blood-to-brain transfer rate, K1, in the same regions of the alcoholic group, with a significant difference in the putamen. K1 was unchanged in the thalamus. The finding of reduced striatal VMAT2 in severe chronic alcoholic patients suggests that nigrostriatal monoaminergic terminals are reduced, with or without loss of neurons from the substantia nigra. The findings suggest that the damaging effects of severe chronic alcoholism on the central nervous system are more extensive than previously considered.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalAnnals of neurology
Volume44
Issue number3
DOIs
StatePublished - Sep 1998

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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