Decreased quality of peripheral blood progenitors collected after a peripheral blood progenitor transplant

A. Miller, D. Morrison, H. Safah, S. Cullins, V. Larussa, J. Rink, R. Weiner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of this study was to determine the quality of peripheral blood progenitor cells (PBPC) collected after an initial autologous PBPC transplant. Tandem autologous transplants have been used in the treatment of several malignancies. Routinely, PBPC have been collected prior to the first transplant and used for both transplants. In the current study, PBPC harvested prior to the first high-dose therapy (HDT) were used as a source of progenitors for transplant 1, and a combination of bone marrow harvested prior to the first course of HDT and PBPC collected approximately 85 days after the first transplant were used to support the second HDT. We analyzed the quality of the PBPC collected 85-120 days after HDT and autologous PBPC transplant. CD34 and colony-forming units granulocyte-macrophage (CFU-GM) contents of those collections were poor, and hematopoietic recovery was more consistent with recovery from a bone marrow transplant than a PBPC transplant. Thirteen of 15 patients received both transplants. Days to absolute granulocyte count of 500 was 10 ± 1.5 for the first transplant and 13.3 ± 3.7 for the second (p < 0.01). The number of days to platelet count of 20,000 was 14.3 ± 10.7 for the first transplant and 18 ± 7 for the second transplant (p = 0.066). The number of days of total parenteral nutrition (TPN) and intravenous morphine used by patients for the first and second transplants was similar, whereas the length of hospitalization was 21.8 ± 3.6 for the first transplant and 27.6 ± 7.8 for the second transplant (NS). In conclusion, it appears that the quality of PBPC collected following a previous PBPC transplant may be compromised.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalJournal of Hematotherapy and Stem Cell Research
Volume9
Issue number4
DOIs
StatePublished - Oct 2 2000

Fingerprint

Transplants
Blood Cells
Stem Cells
Bone Marrow
Therapeutics
Granulocyte-Macrophage Progenitor Cells
Total Parenteral Nutrition
Autografts
Platelet Count
Granulocytes
Morphine
Hospitalization

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Decreased quality of peripheral blood progenitors collected after a peripheral blood progenitor transplant. / Miller, A.; Morrison, D.; Safah, H.; Cullins, S.; Larussa, V.; Rink, J.; Weiner, R.

In: Journal of Hematotherapy and Stem Cell Research, Vol. 9, No. 4, 02.10.2000, p. 475-480.

Research output: Contribution to journalArticle

Miller, A. ; Morrison, D. ; Safah, H. ; Cullins, S. ; Larussa, V. ; Rink, J. ; Weiner, R. / Decreased quality of peripheral blood progenitors collected after a peripheral blood progenitor transplant. In: Journal of Hematotherapy and Stem Cell Research. 2000 ; Vol. 9, No. 4. pp. 475-480.
@article{f8757d1a5cd9423c91af9480711bdb8a,
title = "Decreased quality of peripheral blood progenitors collected after a peripheral blood progenitor transplant",
abstract = "The purpose of this study was to determine the quality of peripheral blood progenitor cells (PBPC) collected after an initial autologous PBPC transplant. Tandem autologous transplants have been used in the treatment of several malignancies. Routinely, PBPC have been collected prior to the first transplant and used for both transplants. In the current study, PBPC harvested prior to the first high-dose therapy (HDT) were used as a source of progenitors for transplant 1, and a combination of bone marrow harvested prior to the first course of HDT and PBPC collected approximately 85 days after the first transplant were used to support the second HDT. We analyzed the quality of the PBPC collected 85-120 days after HDT and autologous PBPC transplant. CD34 and colony-forming units granulocyte-macrophage (CFU-GM) contents of those collections were poor, and hematopoietic recovery was more consistent with recovery from a bone marrow transplant than a PBPC transplant. Thirteen of 15 patients received both transplants. Days to absolute granulocyte count of 500 was 10 ± 1.5 for the first transplant and 13.3 ± 3.7 for the second (p < 0.01). The number of days to platelet count of 20,000 was 14.3 ± 10.7 for the first transplant and 18 ± 7 for the second transplant (p = 0.066). The number of days of total parenteral nutrition (TPN) and intravenous morphine used by patients for the first and second transplants was similar, whereas the length of hospitalization was 21.8 ± 3.6 for the first transplant and 27.6 ± 7.8 for the second transplant (NS). In conclusion, it appears that the quality of PBPC collected following a previous PBPC transplant may be compromised.",
author = "A. Miller and D. Morrison and H. Safah and S. Cullins and V. Larussa and J. Rink and R. Weiner",
year = "2000",
month = "10",
day = "2",
doi = "10.1089/152581600419134",
language = "English",
volume = "9",
pages = "475--480",
journal = "Stem Cells and Development",
issn = "1547-3287",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Decreased quality of peripheral blood progenitors collected after a peripheral blood progenitor transplant

AU - Miller, A.

AU - Morrison, D.

AU - Safah, H.

AU - Cullins, S.

AU - Larussa, V.

AU - Rink, J.

AU - Weiner, R.

PY - 2000/10/2

Y1 - 2000/10/2

N2 - The purpose of this study was to determine the quality of peripheral blood progenitor cells (PBPC) collected after an initial autologous PBPC transplant. Tandem autologous transplants have been used in the treatment of several malignancies. Routinely, PBPC have been collected prior to the first transplant and used for both transplants. In the current study, PBPC harvested prior to the first high-dose therapy (HDT) were used as a source of progenitors for transplant 1, and a combination of bone marrow harvested prior to the first course of HDT and PBPC collected approximately 85 days after the first transplant were used to support the second HDT. We analyzed the quality of the PBPC collected 85-120 days after HDT and autologous PBPC transplant. CD34 and colony-forming units granulocyte-macrophage (CFU-GM) contents of those collections were poor, and hematopoietic recovery was more consistent with recovery from a bone marrow transplant than a PBPC transplant. Thirteen of 15 patients received both transplants. Days to absolute granulocyte count of 500 was 10 ± 1.5 for the first transplant and 13.3 ± 3.7 for the second (p < 0.01). The number of days to platelet count of 20,000 was 14.3 ± 10.7 for the first transplant and 18 ± 7 for the second transplant (p = 0.066). The number of days of total parenteral nutrition (TPN) and intravenous morphine used by patients for the first and second transplants was similar, whereas the length of hospitalization was 21.8 ± 3.6 for the first transplant and 27.6 ± 7.8 for the second transplant (NS). In conclusion, it appears that the quality of PBPC collected following a previous PBPC transplant may be compromised.

AB - The purpose of this study was to determine the quality of peripheral blood progenitor cells (PBPC) collected after an initial autologous PBPC transplant. Tandem autologous transplants have been used in the treatment of several malignancies. Routinely, PBPC have been collected prior to the first transplant and used for both transplants. In the current study, PBPC harvested prior to the first high-dose therapy (HDT) were used as a source of progenitors for transplant 1, and a combination of bone marrow harvested prior to the first course of HDT and PBPC collected approximately 85 days after the first transplant were used to support the second HDT. We analyzed the quality of the PBPC collected 85-120 days after HDT and autologous PBPC transplant. CD34 and colony-forming units granulocyte-macrophage (CFU-GM) contents of those collections were poor, and hematopoietic recovery was more consistent with recovery from a bone marrow transplant than a PBPC transplant. Thirteen of 15 patients received both transplants. Days to absolute granulocyte count of 500 was 10 ± 1.5 for the first transplant and 13.3 ± 3.7 for the second (p < 0.01). The number of days to platelet count of 20,000 was 14.3 ± 10.7 for the first transplant and 18 ± 7 for the second transplant (p = 0.066). The number of days of total parenteral nutrition (TPN) and intravenous morphine used by patients for the first and second transplants was similar, whereas the length of hospitalization was 21.8 ± 3.6 for the first transplant and 27.6 ± 7.8 for the second transplant (NS). In conclusion, it appears that the quality of PBPC collected following a previous PBPC transplant may be compromised.

UR - http://www.scopus.com/inward/record.url?scp=0033825984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033825984&partnerID=8YFLogxK

U2 - 10.1089/152581600419134

DO - 10.1089/152581600419134

M3 - Article

C2 - 10982245

AN - SCOPUS:0033825984

VL - 9

SP - 475

EP - 480

JO - Stem Cells and Development

JF - Stem Cells and Development

SN - 1547-3287

IS - 4

ER -