Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS

W. D. Rooney, R. G. Miller, D. Gelinas, N. Schuff, A. A. Maudsley, M. W. Weiner

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

The primary objectives of this study were to test whether 1) N- acetylaspartate (NAA), a neuronal marker, is reduced in motor cortex and corticospinal-tract (CST) brain regions of ALS patients; and 2) motor cortex NAA correlates to a clinical measurement of upper motor neuron function in ALS patients. Ten probable or definite patients and nine neurologically normal control subjects were studied. Three axial planes of two-dimensional 1H MRSI data were collected, using a single spin-echo multislice sequence (TE140/TR2000). Two of the 1H MRSI planes were positioned superior to the lateral ventricles, and one plane was positioned at the level of the internal capsule. Spectroscopy voxels were selected from motor cortex, frontal cortex, parietal cortex, medial gray matter, centrum semiovale white matter, anterior internal capsule, and posterior internal capsule. Peak integrals were obtained for the three major ~H MRSI singlet resonances, NAA, creatine and phosphocreatine (Cr), and cholines (Cho). Maximum finger-tap rate was used as a clinical measurement of upper motor neuron function. In ALS, brain NAA/(Cho+Cr) was reduced 19% (p = 0.024) in the motor cortex and 16% (p = 0.021) in the CST (centrum semiovale and posterior internal capsule) regions. NAA/(Cho+Cr) was not reduced in frontal cortex, parietal cortex, medial gray matter, or anterior internal capsule. There was a significant relation between ALS motor cortex NAA/(Cho+Cr) and maximum finger-tap rate (r = 0.80; p = 0.014). NAA/(Cho+Cr) was reduced in motor cortex and CST regions and unchanged in other brain regions of ALS patients when compared with controls. These findings are consistent with the known distribution of neuronal loss in ALS. The positive correlation between motor cortex NAA/(Cho + Cr) and maximum finger-tap rate suggests that reduced NAA/(Cho+Cr) is a surrogate marker of motor cortex neuron loss in ALS. These findings support the study of 1H MRSI NAA measurement as an objective and quantitative measurement of upper motor neuron dysfunction in ALS.

Original languageEnglish (US)
Pages (from-to)1800-1805
Number of pages6
JournalNeurology
Volume50
Issue number6
DOIs
StatePublished - Jun 1998
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS'. Together they form a unique fingerprint.

  • Cite this

    Rooney, W. D., Miller, R. G., Gelinas, D., Schuff, N., Maudsley, A. A., & Weiner, M. W. (1998). Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS. Neurology, 50(6), 1800-1805. https://doi.org/10.1212/WNL.50.6.1800