Decreased levels of both Stat1 and Stat3 in T lymphocytes from mice bearing mammary tumors

Mary Ellen Handel-Fernandez, Dan Ilkovitch, Vijaya Iragavarapu-Charyulu, Lynn M. Herbert, Diana M. Lopez

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Lymphocytes from tumor-bearing animals have been shown to lack antitumor function. The objective of this study was to investigate the status of the signal transducers, Stat1 and Stat3, in T lymphocytes of animals bearing D1-DMBA-3 mammary tumors and to elucidate if any alterations in these signal transducers can be explained by the presence of tumor-derived factors and correlated with the lack of antitumor function in these cells. Materials and Methods: T Lymphocytes from spleens of normal and tumor-bearing mice were purified and assayed for the presence of Stat1 and Stat3 by Western blot analysis. Results: It was found that levels of both Stat1 and Stat3 were reduced in T lymphocytes of tumor-bearers not only in their active, phosphorylated form but in total protein levels. Conclusion: These findings indicate that during mammary tumor progression, alteration of various transcription factors may contribute to the down-regulation of immune function.

Original languageEnglish (US)
Pages (from-to)2051-2058
Number of pages8
JournalAnticancer research
Volume29
Issue number6
StatePublished - Jun 1 2009

Keywords

  • Cancer
  • Immunosuppression
  • Lymphocytes
  • Stat

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Handel-Fernandez, M. E., Ilkovitch, D., Iragavarapu-Charyulu, V., Herbert, L. M., & Lopez, D. M. (2009). Decreased levels of both Stat1 and Stat3 in T lymphocytes from mice bearing mammary tumors. Anticancer research, 29(6), 2051-2058.