Decreased histamine H1 receptor binding in the brain of depressed patients

Michiko Kano, Shin Fukudo, Atshushi Tashiro, Atshushi Utsumi, Daisaku Tamura, Masatoshi Itoh, Ren Iwata, Manabu Tashiro, Hideki Mochizuki, Yoshihito Funaki, Motohisa Kato, Michio Hongo, Kazuhiko Yanai

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

The central histaminergic neuron system modulates the wakefulness, sleep-awake cycle, appetite control, learning and memory, and emotion. Previous studies have reported changes in neuronal histamine release and its metabolism under stress conditions in the mammalian brain. In this study, we examined, using positron emission tomography (PET) and [11C]-doxepin, whether the histaminergic neuron system is involved in human depression. Cerebral histamine H1 receptor (H1R) binding was measured in 10 patients with major depression and in 10 normal age-matched subjects using PET and [ 11C]-doxepin. Data were calculated by a graphical analysis on voxel-by-voxel and ROI (region of interests) basis. Binding potential (BP) values for [11C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. There was no area of the brain where [11C]-doxepin binding was significantly higher in the depressed patients than in the controls. ROI-based analysis also revealed that BP values for [11C]-doxepin binding in the frontal cortex and cingulate gyrus decreased in proportion to self-rating depressive scales scores. The results of this study demonstrate that depressed patients have decreased brain H 1R binding and that this decrease correlates with the severity of depression symptoms. It is therefore suggested that the histaminergic neuron system plays an important role in the pathophysiology of depression and that its modulation may prove to be useful in the treatment of depression.

Original languageEnglish (US)
Pages (from-to)803-810
Number of pages8
JournalEuropean Journal of Neuroscience
Volume20
Issue number3
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

Keywords

  • Depression
  • Histamine H receptors
  • Histamine neurons
  • PET
  • Receptor imaging

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kano, M., Fukudo, S., Tashiro, A., Utsumi, A., Tamura, D., Itoh, M., Iwata, R., Tashiro, M., Mochizuki, H., Funaki, Y., Kato, M., Hongo, M., & Yanai, K. (2004). Decreased histamine H1 receptor binding in the brain of depressed patients. European Journal of Neuroscience, 20(3), 803-810. https://doi.org/10.1111/j.1460-9568.2004.03540.x