Decreased activity of cytidine 3′

5′-monophosphate (cyclic CMP) phosphodiesterase in the fast-growing Morris hepatoma 3924A, but not in the slow-growing Morris hepatoma 9618A

Mamoru Shoji, Nancy Brackett, David M. Helfman, Harolf P. Morris, J. F. Kuo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The activity level of the newly-identified cyclic CMP phosphodiesterase in the fast-growing Morris hepatoma 3924A was found to be much lower than the control (normal or host) liver. Its level in the slow-growing Morris hepatoma 9618A (a minimal deviation tumor), on the other hand, was the same as the host liver. The level of cyclic AMP phosphodiesterase was higher, whereas that of cyclic GMP phosphodiesterase was lower, in hepatoma 3924A than the control liver. In comparison, the levels of the two enzymes were both depressed in hepatoma 9618A. These findings suggest that depression of cyclic CMP phosphodiesterase may be related to the process and the rate of malignant growth, and that metabolism of cyclic CMP may be more crucial than that of cyclic AMP or cyclic GMP in the neoplastic cell proliferation.

Original languageEnglish
Pages (from-to)1140-1146
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume83
Issue number3
DOIs
StatePublished - Aug 14 1978
Externally publishedYes

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2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
Experimental Liver Neoplasms
Cytidine
Liver
Cyclic GMP
Phosphoric Diester Hydrolases
Cyclic AMP
Cyclic CMP
Hepatocellular Carcinoma
Cell proliferation
Metabolism
Tumors
Cell Proliferation
Enzymes
Growth
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Decreased activity of cytidine 3′ : 5′-monophosphate (cyclic CMP) phosphodiesterase in the fast-growing Morris hepatoma 3924A, but not in the slow-growing Morris hepatoma 9618A. / Shoji, Mamoru; Brackett, Nancy; Helfman, David M.; Morris, Harolf P.; Kuo, J. F.

In: Biochemical and Biophysical Research Communications, Vol. 83, No. 3, 14.08.1978, p. 1140-1146.

Research output: Contribution to journalArticle

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abstract = "The activity level of the newly-identified cyclic CMP phosphodiesterase in the fast-growing Morris hepatoma 3924A was found to be much lower than the control (normal or host) liver. Its level in the slow-growing Morris hepatoma 9618A (a minimal deviation tumor), on the other hand, was the same as the host liver. The level of cyclic AMP phosphodiesterase was higher, whereas that of cyclic GMP phosphodiesterase was lower, in hepatoma 3924A than the control liver. In comparison, the levels of the two enzymes were both depressed in hepatoma 9618A. These findings suggest that depression of cyclic CMP phosphodiesterase may be related to the process and the rate of malignant growth, and that metabolism of cyclic CMP may be more crucial than that of cyclic AMP or cyclic GMP in the neoplastic cell proliferation.",
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