Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia

Delfina de Achával, Mirta F. Villarreal, Elsa Y. Costanzo, Jazmín Douer, Mariana N. Castro, Martina C. Mora, Charles Nemeroff, Elvina Chu, Karl Jürgen Bär, Salvador M. Guinjoan

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Social cognitive deficits contribute to functional disability in schizophrenia. Social cognitive tasks in healthy persons consistently evoke activation of medial prefrontal cortex, inferior frontal gyrus, temporoparietal gyrus, and posterior cingulate cortex/precuneus. We tested the hypothesis that patients with schizophrenia and their unaffected siblings share dysfunction of the same neural networks. Methods: Neural activation during emotion processing (EP), theory of mind (ToM), and control tasks was measured using functional magnetic resonance imaging (fMRI) in 14 patients with schizophrenia, 14 nonpsychotic siblings of patients with schizophrenia, and 14 matched healthy subjects. Results: Compared with healthy controls, patients with schizophrenia showed reduced activation of right hemisphere structures involved in EP and ToM including inferior frontal gyrus, middle frontal gyrus, and right temporoparietal junction. These deficits were shared, in part, by unaffected siblings. The latter group demonstrated deficits in bilateral precuneus activation during ToM, not present in patients. Conclusions: Schizophrenia appears to be associated with a deficit in activation of right hemisphere components of a ToM network. Such deficits are shared in part by those at high genetic risk but unaffected by schizophrenia.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalSchizophrenia Research
Volume134
Issue number2-3
DOIs
StatePublished - Feb 1 2012

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Cognition
Siblings
Schizophrenia
Theory of Mind
Prefrontal Cortex
Parietal Lobe
Emotions
Gyrus Cinguli
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • FMRI
  • Lateralization
  • Schizophrenia
  • Siblings
  • Social cognition
  • Theory of mind

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

de Achával, D., Villarreal, M. F., Costanzo, E. Y., Douer, J., Castro, M. N., Mora, M. C., ... Guinjoan, S. M. (2012). Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia. Schizophrenia Research, 134(2-3), 171-179. https://doi.org/10.1016/j.schres.2011.11.010

Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia. / de Achával, Delfina; Villarreal, Mirta F.; Costanzo, Elsa Y.; Douer, Jazmín; Castro, Mariana N.; Mora, Martina C.; Nemeroff, Charles; Chu, Elvina; Bär, Karl Jürgen; Guinjoan, Salvador M.

In: Schizophrenia Research, Vol. 134, No. 2-3, 01.02.2012, p. 171-179.

Research output: Contribution to journalArticle

de Achával, D, Villarreal, MF, Costanzo, EY, Douer, J, Castro, MN, Mora, MC, Nemeroff, C, Chu, E, Bär, KJ & Guinjoan, SM 2012, 'Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia', Schizophrenia Research, vol. 134, no. 2-3, pp. 171-179. https://doi.org/10.1016/j.schres.2011.11.010
de Achával, Delfina ; Villarreal, Mirta F. ; Costanzo, Elsa Y. ; Douer, Jazmín ; Castro, Mariana N. ; Mora, Martina C. ; Nemeroff, Charles ; Chu, Elvina ; Bär, Karl Jürgen ; Guinjoan, Salvador M. / Decreased activity in right-hemisphere structures involved in social cognition in siblings discordant for schizophrenia. In: Schizophrenia Research. 2012 ; Vol. 134, No. 2-3. pp. 171-179.
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