Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy

D. A. Palay, P. Sternberg, J. Davis, H. Lewis, G. N. Holland, W. F. Mieler, D. A. Jabs, C. Drews

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137 Scopus citations

Abstract

We reviewed the course of 54 patients who had unilateral acute retinal necrosis at initial examination. Thirty-one patients were treated with acyclovir, whereas 23 were not. Of the 31 patients treated with acyclovir, 27 (87.1%) had fellow eyes that remained disease-free throughout a median follow-up of 12 months. Of the 23 patients not treated with acyclovir, seven (30.4%) had fellow eyes that remained disease-free throughout a median follow-up of 11 months. Survival analysis indicated that the fellow eyes of the group of patients treated with acyclovir were more likely to remain disease-free than the fellow eyes of the group not treated with acyclovir (P = .0013). Two years after initial onset, the proportion of fellow eyes that remained disease-free was 75.3% for the group treated with acyclovir and 35.1% for the group not treated with acyclovir. These results suggest that acyclovir treatment reduces the risk of involvement of the fellow eye in patients with acute retinal necrosis.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalAmerican journal of ophthalmology
Volume112
Issue number3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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    Palay, D. A., Sternberg, P., Davis, J., Lewis, H., Holland, G. N., Mieler, W. F., Jabs, D. A., & Drews, C. (1991). Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy. American journal of ophthalmology, 112(3), 250-255. https://doi.org/10.1016/S0002-9394(14)76725-X